“…3,4-Methylenedioxymethamphetamine (MDMA, Scheme 1) is a synthetic entactogen which shares a structural similarity to methamphetamine and acts as a central nervous system (CNS) stimulant producing mood enhancement, increased energy and other empathetic effects by increasing the intra-synaptic concentrations of the key neurotransmitters serotonin, dopamine and norephinephrine. [1][2][3][4][5] MDMA was rst synthesised by Merck in 1912 as a potential appetite suppressant, and over the next seventy years, a number of researchers explored the psychedelic properties of MDMA with little success. 6 During the 1970s and 80s MDMA surfaced on the recreational drugs market, its widespread abuse and potential long-term health effects led many countries to prohibit its possession, supply and manufacture.…”