Methylene blue and photodynamic therapy for melanomas: Inducing different rates of cell death (necrosis and apoptosis) in B16-F10 melanoma cells according to methylene blue concentration and energy dose

Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)∞ for oral drug delivery

“…The apoptosis assay was performed using annexin V-FITC/propidium iodide (PI) double staining. 73 Briefly, BJ-5ta cells were seeded in 6-well plates at a density of 1 × 10 5 cells per well and incubated overnight under standard conditions. The cells were treated with 400 mg L −1 Sr(BDC)(DMF), Sr(BDC) and Sr(BDC)(260 °C).…”

Clinical effectiveness and prospects of methylene blue: A systematic review

“…It is plausible that mitochondria are involved in MB PDT-induced tumor regression because MB is likely to bind to the mitochondrial matrix in a negative electrochemical environment [96]. Researchers have shown that MB PDT is effective against melanoma in both human and animal studies where large melanoma lesions that could not be surgically removed were effectively treated [81,97,98]. The clinical applications of MB PDT may still be limited, particularly for deeply seated hypoxic tumors.…”