Méthylation de l’ADN mitochondrial

LeRoux, E.F.; Brosseau, Cindy; Angers, Bernard; Angers, Annie; Breton, Sophie

doi:10.1051/medsci/2021011

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…DNA methylation is the most well-known epigenetic mechanism [ 70 ]. Its role is particularly important in the regulation of gene expression, which is crucial for normal human development [ 71 ]. As a result of DNA methylation, a covalent attachment of a methyl group (–CH3) to cytosine or adenine is observed, using the enzyme DNA methyltransferase (DNMT) and S-adenosylmethionine (SAM) as a donor of the methyl group [ 72 ].…”

Section: Epigenetic Factorsmentioning

confidence: 99%

The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Jarmakiewicz-Czaja

Sokal

Ferenc

et al. 2023

Genes

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Inflammatory bowel diseases (IBDs) are a group of chronic diseases characterized by recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most common complications of IBD. Based on current analyses, it is evident that genetic factors and mechanisms, as well as epigenetic factors, play a role in the induction and progression of intestinal fibrosis in IBD. Key genetic factors and mechanisms that appear to be significant include NOD2, TGF-β, TLRs, Il23R, and ATG16L1. Deoxyribonucleic acid (DNA) methylation, histone modification, and ribonucleic acid (RNA) interference are the primary epigenetic mechanisms. Genetic and epigenetic mechanisms, which seem to be important in the pathophysiology and progression of IBD, may potentially be used in targeted therapy in the future. Therefore, the aim of this study was to gather and discuss selected mechanisms and genetic factors, as well as epigenetic factors.

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Section: Epigenetic Factorsmentioning

confidence: 99%

The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Jarmakiewicz-Czaja

Sokal

Ferenc

et al. 2023

Genes

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“…The number of hydrogen bonds determines the specific pairing between nitrogenous bases, but this structure is prone to errors and can sometimes be repaired [4] [5] .…”

Section: Introductionmentioning

confidence: 99%

Enhancing Multiple Sequence Alignment with Genetic Algorithms: A Bioinformatics Approach in Biomedical Engineering

Rios-Willars,

Velez-Segura,

Delabra-Salinas

2024

Rev. Mex. Ing. Biomed.

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This study aimed to create a genetic information processing technique for the problem of multiple alignment of genetic sequences in bioinformatics. The objective was to take advantage of the computer hardware's capabilities and analyze the results obtained regarding quality, processing time, and the number of evaluated functions. The methodology was based on developing a genetic algorithm in Java, which resulted in four different versions: Gp1, Gp2, Gp3 and Gp4 . A set of genetic sequences were processed, and the results were evaluated by analyzing numerical behavior profiles. The research found that algorithms that maintained diversity in the population produced better quality solutions, and parallel processing reduced processing time. It was observed that the time required to perform the process decreased, according to the generated performance profile. The study concluded that conventional computer equipment can produce excellent results when processing genetic information if algorithms are optimized to exploit hardware resources. The computational effort of the hardware used is directly related to the number of evaluated functions. Additionally, the comparison method based on the determination of the performance profile is highlighted as a strategy for comparing the algorithm results in different metrics of interest, which can guide the development of more efficient genetic information processing techniques.

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Mitochondrial Short-Term Plastic Responses and Long-Term Evolutionary Dynamics in Animal Species

Breton

Ghiselli

Milani

2021

Genome Biology and Evolution

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How do species respond or adapt to environmental changes? The answer to this depends partly on mitochondrial epigenetics and genetics, new players in promoting adaptation to both short- and long-term environmental changes. In this review, we explore how mitochondrial epigenetics and genetics mechanisms, such as mtDNA methylation, mtDNA-derived non-coding RNAs, micropeptides, mtDNA mutations and adaptations, can contribute to animal plasticity and adaptation. We also briefly discuss the challenges in assessing mtDNA adaptive evolution. In sum, this review covers new advances in the field of mitochondrial genomics, many of which are still controversial, and discusses processes still somewhat obscure, and some of which are still quite speculative and require further robust experimentation.

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Méthylation de l’ADN mitochondrial

Cited by 3 publications

References 46 publications

The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Enhancing Multiple Sequence Alignment with Genetic Algorithms: A Bioinformatics Approach in Biomedical Engineering

Mitochondrial Short-Term Plastic Responses and Long-Term Evolutionary Dynamics in Animal Species

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