The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Jarmakiewicz-Czaja, Sara; Sokal, Aneta; Ferenc, Katarzyna; Motyka, E.; Helma, Kacper; Filip, Rafał

doi:10.3390/genes14061167

Cited by 7 publications

(4 citation statements)

References 123 publications

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“…They are called CpG islands [71]. DNA hypermethylation of specific genes and general methylation changes are often linked to the induction of many disease processes [72]. DNA methylation is a process under dynamic control.…”

Section: Epigenetic Mechanismmentioning

confidence: 99%

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Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Ferenc,

Sokal-Dembowska,

Helma

et al. 2024

IJMS

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The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in the human body. Existing evidence suggests that nutrients can influence the modulation of the gut microbiota. However, there is still limited evidence regarding the effects of vitamin and mineral supplementation on the human gut microbiota through epigenetic modification. It is plausible that maintaining an adequate dietary intake of vitamin D, iron, fibre, zinc and magnesium may have a beneficial effect on alleviating inflammation in the body, reducing oxidative stress, and improving the condition of the intestinal microbiota through various epigenetic mechanisms. Moreover, epigenetics involves alterations in the phenotype of a cell without changing its fundamental DNA sequence. It appears that the modulation of the microbiota by various nutrients may lead to epigenetic regulation. The correlations between microbiota and epigenetics are potentially interdependent. Therefore, the primary objective of this review is to identify the complex relationships between diet, gut microbiota, and epigenetic regulation. These interactions could play a crucial role in systemic health.

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Section: Epigenetic Mechanismmentioning

confidence: 99%

“…It has been demonstrated that bacteria such as Eubacterium hallii and Anaerostipes spp. can convert acetate and lactate to butyrate [72]. On the other hand, increasing the number of Acetobacterium, Acetogenium, and Clostridium may result in increased production of acetate from butyrate [125].…”

Section: Microbiota Epigenetics and Scfasmentioning

confidence: 99%

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Ferenc,

Sokal-Dembowska,

Helma

et al. 2024

IJMS

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“…This inevitable progression towards fibrosis suggests that fibrosis becomes inflammationindependent and auto-propagative (Santacroce et al, 2022;Park et al, 2023). The course and extent of fibrosis show significant variability between individual patients, indicating a genetic component (Jarmakiewicz-Czaja et al, 2023;Macias-Ceja et al, 2023). In CD, approximately 50% of patients develop fibrotic strictures or penetrating lesions (Cosnes et al, 2011) and it is estimated that up to 70% of patients will eventually require surgery at some point during their disease course (Yoo et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Epithelial Barrier Dysfunction in Disease

Pardo-Pastor,

López Posadas,

Ortiz Zapater

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…This inevitable progression towards fibrosis suggests that fibrosis becomes inflammation-independent and auto-propagative ( Santacroce et al, 2022 ; Park et al, 2023 ). The course and extent of fibrosis show significant variability between individual patients, indicating a genetic component ( Jarmakiewicz-Czaja et al, 2023 ; Macias-Ceja et al, 2023 ). In CD, approximately 50% of patients develop fibrotic strictures or penetrating lesions ( Cosnes et al, 2011 ) and it is estimated that up to 70% of patients will eventually require surgery at some point during their disease course ( Yoo et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition

Macias-Ceja,

Mendoza-Ballesteros,

Ortega-Albiach

et al. 2023

Front. Cell Dev. Biol.

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In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged injury and inflammation can trigger the activation of fibroblasts and extracellular matrix (ECM) components. As fibrosis progresses, the tissue becomes increasingly stiff and less functional, which can lead to complications such as intestinal strictures, obstructive symptoms, and eventually, organ dysfunction. Epithelial cells play a key role in fibrosis, as they secrete cytokines and growth factors that promote fibroblast activation and ECM deposition. Additionally, epithelial cells can undergo a process called epithelial-mesenchymal transition, in which they acquire a more mesenchymal-like phenotype and contribute directly to fibroblast activation and ECM deposition. Overall, the interactions between epithelial cells, immune cells, and fibroblasts play a critical role in the development and progression of fibrosis in IBD. Understanding these complex interactions may provide new targets for therapeutic interventions to prevent or treat fibrosis in IBD. In this review, we have collected and discussed the recent literature highlighting the contribution of epithelial cells to the pathogenesis of the fibrotic complications of IBD, including evidence of EMT, the epigenetic control of the EMT, the potential influence of the intestinal microbiome in EMT, and the possible therapeutic strategies to target EMT. Finally we discuss the pro-fibrotic interactions epithelial-immune cells and epithelial-fibroblasts cells.

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The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Cited by 7 publications

References 123 publications

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Epithelial Barrier Dysfunction in Disease

Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition

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