Methylated<i>claudin-11</i>associated with metastasis and poor survival of colorectal cancer

Li, Jinyun; Zhou, Chongchang; Ni, Shumin; Wang, Shaomin; Yang, Ping; Meng, Yan

doi:10.18632/oncotarget.21997

Cited by 22 publications

(18 citation statements)

References 48 publications

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“…In addition, the methylation profile of gene promoters was different for each type of tumor [46], suggesting that the detection of aberrant gene promoter methylation could serve as a potential molecular biomarker for tumors. The evaluation of methylation profiles as a tool for the diagnosis or prognosis of tumors has been described for many cancers, such as colorectal cancer [52], nasopharyngeal carcinoma [53], laryngeal squamous cell carcinoma [54], and HNSCC [55].…”

Section: Discussionmentioning

confidence: 99%

DNA methylation biomarkers for head and neck squamous cell carcinoma

Zhou

et al. 2018

Epigenetics

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DNA methylation plays an important role in the etiology and pathogenesis of head and neck squamous cell carcinoma (HNSCC). The current study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) by a comprehensive bioinformatics analysis. In addition, we screened for DEGs affected by DNA methylation modification and further investigated their prognostic values for HNSCC. We included microarray data of DNA methylation (GSE25093 and GSE33202) and gene expression (GSE23036 and GSE58911) from Gene Expression Omnibus. Aberrantly methylated-DEGs were analyzed with R software. The Cancer Genome Atlas (TCGA) RNA sequencing and DNA methylation (Illumina HumanMethylation450) databases were utilized for validation. In total, 27 aberrantly methylated genes accompanied by altered expression were identified. After confirmation by The Cancer Genome Atlas (TCGA) database, 2 hypermethylated-low-expression genes (FAM135B and ZNF610) and 2 hypomethylated-high-expression genes (HOXA9 and DCC) were identified. A receiver operating characteristic (ROC) curve confirmed the diagnostic value of these four methylated genes for HNSCC. Multivariate Cox proportional hazards analysis showed that FAM135B methylation was a favorable independent prognostic biomarker for overall survival of HNSCC patients.

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Section: Discussionmentioning

confidence: 99%

DNA methylation biomarkers for head and neck squamous cell carcinoma

Zhou

et al. 2018

Epigenetics

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“…Methylation levels of the HOXA9 promoter (chr7:27206577‐27206704) in 145 HNSCC and paired adjacent tissue samples were determined using a qMSP assay as described previously . ACTB was chosen as the internal control and human methylated DNA (Zymo Research, Orange, CA, USA) served as the positive control.…”

Section: Methodsmentioning

confidence: 99%

“…Methylation levels of the HOXA9 promoter (chr7:27206577-27206704) in 145 HNSCC and paired adjacent tissue samples were determined using a qMSP assay as described previously. 31 ACTB was chosen as the internal control 28 and human methylated DNA ( were used to evaluate HOXA9 methylation in this dataset. Receiver operating characteristic (ROC) analysis was used to assess the diagnostic value of HOXA9 methylation for HNSCC.…”

Section: Quantitative Methylation-specific Polymerase Chain Reactiomentioning

confidence: 99%

The clinical significance of HOXA9 promoter hypermethylation in head and neck squamous cell carcinoma

Zhou

et al. 2019

Clinical Laboratory Analysis

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BackgroundThe purpose of the current study was to assess the association between HOXA9 (homeobox A9) promoter methylation and head and neck squamous cell carcinoma (HNSCC) and its diagnostic value.MethodsQuantitative methylation‐specific PCR (qMSP) was applied to measure HOXA9 promoter methylation levels in 145 paired HNSCC and corresponding normal tissue samples. Data from the Cancer Genome Atlas (TCGA) database (n = 578; 528 HNSCC and 50 normal) were also analyzed.ResultsSignificantly higher levels of HOXA9 promoter methylation were detected in HNSCC, compared with normal, tissues (our cohort: P = 1.06E‐35; TCGA cohort: P = 3.06E‐39). Moreover, HOXA9 methylation was significantly increased in patients with advanced tumor (T) stage, lymph node metastasis, and advanced clinical stage. Areas under the receiver characteristic curves (AUCs) based on our cohort and TCGA data were 0.930 and 0.967, respectively.ConclusionIn summary, our study reveals that HOXA9 promoter hypermethylation contributes to the risk of HNSCC and its progression and metastasis. Additionally, HOXA9 hypermethylation is a potential biomarker for the early diagnosis and screening of patients with HNSCC.

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“…Tight junctions are involved in extravasation and angiogenesis [111]. Claudin-11 hyper-methylation is linked to colon cancer progression and metastasis [112].…”

Section: Pro-angiogenic Mirnas In Crcmentioning

confidence: 99%

Angioregulatory microRNAs in Colorectal Cancer

Soheilifar

Grusch

Neghab

et al. 2019

Cancers

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Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Angiogenesis is a rate-determining step in CRC development and metastasis. The balance of angiogenic and antiangiogenic factors is crucial in this process. Angiogenesis-related genes can be regulated post-transcriptionally by microRNAs (miRNAs) and some miRNAs have been shown to shuttle between tumor cells and the tumor microenvironment (TME). MiRNAs have context-dependent actions and can promote or suppress angiogenesis dependent on the type of cancer. On the one hand, miRNAs downregulate anti-angiogenic targets and lead to angiogenesis induction. Tumor suppressor miRNAs, on the other hand, enhance anti-angiogenic response by targeting pro-angiogenic factors. Understanding the interaction between these miRNAs and their target mRNAs will help to unravel molecular mechanisms involved in CRC progression. The aim of this article is to review the current literature on angioregulatory miRNAs in CRC.

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Methylatedclaudin-11associated with metastasis and poor survival of colorectal cancer

Cited by 22 publications

References 48 publications

DNA methylation biomarkers for head and neck squamous cell carcinoma

DNA methylation biomarkers for head and neck squamous cell carcinoma

The clinical significance of HOXA9 promoter hypermethylation in head and neck squamous cell carcinoma

Angioregulatory microRNAs in Colorectal Cancer

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