Methyl Sulfonyl Polychlorinated Biphenyls and 2,2-Bis(4-Chlorophenyl)-1,1-Dichlorethene in Gray Seal Tissues Determined by Gas Chromatography With Electron Capture Detection and Atomic Emission Detection

Abstract

Abstract-The presence of 24 methyl sulfonyl polychlorinated biphenyl (PCB) congeners (MeSO 2 -CBs) and 3-methyl sulfonyl 2,2-bis(4-chlorophenyl)-1,1-dichlorethene (DDE) (MeSO 2 -DDE), metabolites of PCB and DDE, in blubber, lung, and liver of gray seals has been determined by using atomic emission detection (AED) and electron capture detection (ECD). Selective accumulation of aryl methyl sulfones in blubber, liver, and lung tissue was also investigated. For the liver samples, a substantial and highly specific retention of PCB methyl sulfones was observed. The atomic emission technique significantly improved the determination of measured solutes compared with ECD. Atomic emission detection was also valuable for the monitoring of the prefractionation and to decrease the requirements of sample clean-up. Comparing both detection techniques showed a good correlation between the results of the AED sulfur-selective line and ECD.

Enantiomeric Specificity of Methylsulfonyl-PCBs and Distribution of Bis(4-chlorophenyl) Sulfone, PCB, and DDE Methyl Sulfones in Grey Seal Tissues

“…In the present study, median concentrations of the MeSO 2 −PCBs in the grey seal lung and blubber tissues were 0.85 and 1.7 μg/g l.w., respectively, which are in the same ranges as previously reported ( , ). However, MeSO 2 −PCBs show significantly higher levels in the liver ( p < 0.001, ANOVA), with a median ∑MeSO 2 −PCBs of 42 μg/g l.w.…”

“…Two achiral MeSO 2 −PCB congeners, 4-MeSO 2 -2,3,4‘,6-tetraCB (4-MeSO 2 −CB64) and 3-MeSO 2 -2,2‘,3‘,4‘,5-pentaCB (3‘-MeSO 2 −CB87), also showed strong liver retentions, constituting 18 and 16% of the ∑MeSO 2 −PCBs, respectively. A high selectivity for one MeSO 2 −PCB congener has also previously been reported both in human and in grey seal liver but without knowledge of the atropisomeric ratio (e.g., 5‘-MeSO 2 −CB132 made up 60% in humans, and 5-MeSO 2 −CB149 made up 40% in grey seals of ∑MeSO 2 −PCBs ( , )). The distribution of MeSO 2 −PCB congeners in the different tissues in our grey seals, all sampled between year 2000−2001, shows similar congener patterns as have previ ously been reported ( , ).…”

“…A high selectivity for one MeSO 2 −PCB congener has also previously been reported both in human and in grey seal liver but without knowledge of the atropisomeric ratio (e.g., 5‘-MeSO 2 −CB132 made up 60% in humans, and 5-MeSO 2 −CB149 made up 40% in grey seals of ∑MeSO 2 −PCBs ( , )). The distribution of MeSO 2 −PCB congeners in the different tissues in our grey seals, all sampled between year 2000−2001, shows similar congener patterns as have previ ously been reported ( , ). The enantioselective analyses in this study therefore clearly show that the animals are exposed internally with a much higher selectivity than previously known since the optically active MeSO 2 −PCB compounds occur in the body as only one of two possible atropisomers.…”

Risks and Management of Dioxins and Dioxin-like Compounds in Baltic Sea Fish: An Integrated Assessment

“…Several OH-CB and MeSO 2 -CB metabolites of PCBs have been identified , Bergman et al 1994a, Janák et al 1998, see also in Baltic seals that have variable ability to metabolize PCBs (cf. Annex 7C).…”

Atomic Spectrometry Update. Advances in atomic emission, absorption, and fluorescence spectrometry, and related techniques

“…619 The determination of compounds containing hetero-atoms is the other major application of GC-MIP-AES that usually dominates the literature, and this year was no exception, with applications detailing the selective detection of Cl-, S-, N-, P-, O-, As-, F-, Br-and I-containing compounds. [620][621][622][623][624][625][626] Of particular note was: the coupling of a programmable pyrolyzer with MIP-AES and MS for the analysis of pressure sensitive adhesives in adhesive tapes, 627 such that additives were selectively identified by the combined analysis of the two pyrograms; determination of compounds in nerve agents 624 and chemical warfare agents, 625 wherein the element selective nature of the detection allowed the analytes to be quantified even if no standards were available or were too dangerous to use; determination of methyl sulfonyl PCB and DDE in grey seal tissues; 622 and multi-element detection during simulated distillation of diesel oil, 621 resulting in LOD of 0.002 and 0.04% for S and N at 181.379 and 174.2 nm, respectively.…”