Methyl jasmonate induces cell death and loss of hydrogenosomal membrane potential in Trichomonas vaginalis

Vilela, Ricardo Chaves; Menna-Barreto, Rubem F.S.; Benchimol, Marlene

doi:10.1016/j.parint.2010.05.003

Cited by 13 publications

(4 citation statements)

References 29 publications

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“…JC-1 is a fluorescent lipophilic and cationic probe that can be used to determine the mitochondrial and hydrogenosomal ⌬m (28,66). Use of the JC-1 probe revealed that RESV and MDZ induced a loss of ⌬m, suggesting that these agents also produced a metabolic perturbation of the hydrogenosome.…”

Section: Discussionmentioning

confidence: 99%

Hydrogenosome Metabolism Is the Key Target for Antiparasitic Activity of Resveratrol against Trichomonas vaginalis

Mallo

Lamas

Leiro

2013

Antimicrob Agents Chemother

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Section: Discussionmentioning

confidence: 99%

Hydrogenosome Metabolism Is the Key Target for Antiparasitic Activity of Resveratrol against Trichomonas vaginalis

Mallo

Lamas

Leiro

2013

Antimicrob Agents Chemother

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“…Gold et al reported that jasmonates had significant antiparasitic effects on human parasites, Plasmodium falciparum (an intraerythrocytic protozoan parasite, which is the causative agent of the most severe form of malaria), and Schistosoma mansoni (a parasitic worm residing in blood vessels, causing a serious human infestation). Another study indicated that MJ induced a time‐ and dose‐dependent decrease in the number of live Trichomonas vaginalis , an important human parasite of the urogenital tract. Other researchers also reported on the potential of employing MJ as a treatment for trichomoniasis, including its use against metronidazole‐resistant strains.…”

Section: Biological Activities Of Ja Derivativesmentioning

confidence: 99%

A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

Pirbalouti

Sajjadi

Parang

2014

Archiv der Pharmazie

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In medicinal chemistry there is a growing interest in using small molecules, including plant stress hormones. Jasmonic acid (JA) and its volatile methyl ester (MJ), collectively termed jasmonates, are lipid‐derived cyclopentanone compounds that occur ubiquitously and exclusively in the plant kingdom. This review covers the synthesis, usage, and biological activities of JA and its derivatives. A brief overview of the available information on JA and its features is given, followed by a detailed review of JA and its derivatives as drugs and prodrugs; the properties in plants and the synthesis in recent patents are described. This review shows the direction of long‐term drug/nutraceutical safety trials and provides insights for future research in this area. Research on JA continues to be of major interest. Recent innovations offer hope for the development of new therapeutics in related fields. It is anticipated that several analogs can be advanced to preclinical and clinical studies.

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“…The authors suggest that the mitochondria-independent cytotoxicity of methyl jasmonate could enable it to serve as a potential new agent against trichomoniasis. Vilela, Menna-Barreto [ 109 ] confirmed, using flow cytometry and scanning and transmission electron microscopy, that methyl jasmonate induced cell death and loss of hydrogenosomal membrane potential in T. vaginalis .…”

Section: Introductionmentioning

confidence: 94%

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

Friedman

Tam

Cheng

et al. 2020

BMC Complement Med Ther

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Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease that contributes to reproductive morbidity in affected women and possibly to prostate cancer in men. Tritrichomonas foetus strains cause the disease trichomoniasis in farm animals (cattle, bulls, pigs) and diarrhea in domestic animals (cats and dogs). Because some T. vaginalis strains have become resistant to the widely used drug metronidazole, there is a need to develop alternative treatments, based on safe natural products that have the potential to replace and/or enhance the activity of lower doses of metronidazole. To help meet this need, this overview collates and interprets worldwide reported studies on the efficacy of structurally different classes of food, marine, and medicinal plant extracts and some of their bioactive pure compounds against T. vaginalis and T. foetus in vitro and in infected mice and women. Active food extracts include potato peels and their glycoalkaloids α-chaconine and α-solanine, caffeic and chlorogenic acids, and quercetin; the tomato glycoalkaloid α-tomatine; theaflavin-rich black tea extracts and bioactive theaflavins; plant essential oils and their compounds (+)-α-bisabolol and eugenol; the grape skin compound resveratrol; the kidney bean lectin, marine extracts from algae, seaweeds, and fungi and compounds that are derived from fungi; medicinal extracts and about 30 isolated pure compounds. Also covered are the inactivation of drug-resistant T. vaginalis and T. foetus strains by sensitized light; anti-trichomonad effects in mice and women; beneficial effects of probiotics in women; and mechanisms that govern cell death. The summarized findings will hopefully stimulate additional research, including molecular-mechanism-guided inactivations and human clinical studies, that will help ameliorate adverse effects of pathogenic protozoa.

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Methyl jasmonate induces cell death and loss of hydrogenosomal membrane potential in Trichomonas vaginalis

Cited by 13 publications

References 29 publications

Hydrogenosome Metabolism Is the Key Target for Antiparasitic Activity of Resveratrol against Trichomonas vaginalis

Hydrogenosome Metabolism Is the Key Target for Antiparasitic Activity of Resveratrol against Trichomonas vaginalis

A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

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