Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice

Eduviere, Anthony T.; Umukoro, Solomon; Aderibigbe, Adegbuyi Oladele; Ajayi, Abayomi Mayowa; Adewole, F. A.

doi:10.1016/j.lfs.2015.04.007

Cited by 57 publications

(53 citation statements)

References 37 publications

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“…Moreover, cognitive impairment induced by SC or LPS as shown by decrease stepdown latency was also attenuated by MJ. These findings further support our previous studies, which showed that MJ has memory enhancing effect in Y-maze and object recognition animal model of cognition (20)(21).…”

Section: Discussionsupporting

confidence: 92%

“…It is also consumed as tea and used traditionally to relieve stress and tension; for treatment of depression and memory deteriorations [17]. Several studies have highlighted its health benefits against cancer, depression, amnesia and other neuropsychiatric disorders (14,16,(18)(19)(20)(21). Although we have reported in our previous studies that MJ improves memory and attenuated scopolamine or lipopolysaccharideinduced amnesia in object recognition and Y maze tests in mice [20][21], its effect on memory acquisition and consolidation in response to an aversive stimulus in passive avoidance task is yet to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

2017

IJNR

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Passive avoidance task is a rodent model of memory in which the animal learns to avoid an aversive stimulus precipitated by fear and it is always accompanied by inhibition of motor behavior. We have shown in our previous studies that methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum demonstrated memory enhancing effect in hippocampal-dependent memory tasks such as Y-maze and object recognition tests in mice. This present study was designed to investigate if MJ could ameliorate memory deficits associated majorly with the activation of the amygdala in response to an aversive stimulus in the passive avoidance paradigm. The present study also evaluated the effect of MJ on scopolamine (SC)-and lipopolysaccharide (LPS)-induced memory impairment in the passive avoidance paradigm. Mice were given intraperitoneal (i.p) injection of MJ (10-40 mg/kg), donepezil, DP (1 mg/kg) or vehicle daily for 7 days before testing for memory using passive avoidance stepdown apparatus. In the interaction studies, the effects of SC (3 mg/kg, i.p.) or LPS (250 µg/kg, i.p.) given alone or with MJ (10, 20, 40 mg/kg) or DP (1 mg/kg) for 7 consecutive days were also evaluated. SC and LPS were injected 30 min after MJ or DP administration. The time it took (step-down latency) the mouse to step down from the elevated vibrating platform onto the grids (electrified stainless steel bars on the floor of the cage), which indicates memory function was recorded. Our findings revealed

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

2017

IJNR

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“…Although MJ is widely used to treat depression, nervousness, and improve memory in aromatherapy, the finding that MJ demonstrated sedative effect and enhanced GABA currents [Hossain et al, ] provided the first experimental evidences supporting a mechanistic basis for its therapeutic benefits in neuropsychiatric disorders. Moreover, MJ demonstrated adaptogenic, antiamnesic, and antipsychotic activities in rodents [Eduviere et al, ; Umukoro et al, ; Annafi et al, ] and exhibited antidepressant‐like activity in mice subjected to acute stress models of forced swimming (FST) and tail suspension (TST) tests. It also attenuated depressive‐like symptoms induced by lipopolysaccharide in mice [Umukoro et al, ; Adebesin et al, ].…”

Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Adebesin

Ajayi

Olonode

et al. 2017

Drug Development Research

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Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant-like activity. MJ also reduced UCMS-induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS-induced decreases in GSH and TNF-α levels and SOD activity. These findings suggest that MJ attenuated UCMS-induced depressive-like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381-389, 2017. © 2017 Wiley Periodicals, Inc.

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“…The doses of naringin used in this study were selected based on the results obtained from preliminary investigations, which consisted of brief tests on the different behavioral test paradigms using different doses of test compound, so as to get the best active dose range. The dose of DZP [25], IMIP [26] and DPZ [27] were based on previous studies, and they were used as reference drugs for the anxiolytic, anti-depressant and memory enhancing effects, respectively.…”

Section: Drugs Procurements and Preparationsmentioning

confidence: 99%

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

et al. 2018

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Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice

Cited by 57 publications

References 37 publications

Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

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