Methyl Angolensate: The Antiulcer Agent of the Stem Bark of<i>Entandrophragma angolense</i>

Njar, Vincent C.O.; Adesanwo, Julius K.; Raji, Yinusa

doi:10.1055/s-2006-958015

Cited by 66 publications

(47 citation statements)

References 2 publications

(2 reference statements)

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“…The effect of 2'-[5-Chloro-2-hydroxybenzylidene] benzenesulfanohydrazide compound on the acidity of gastric juice relative to that of the cimetidine group agrees with the findings of Murakamu & Njar [9,10].…”

Section: Discussionsupporting

confidence: 88%

Synthesis of 2’-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats

Gwaram¹,

Musalam²,

Ali³

et al. 2012

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 88%

Synthesis of 2’-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats

Gwaram¹,

Musalam²,

Ali³

et al. 2012

Trop. J. Pharm Res

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“…The sum of the areas of all lesions for each stomach was applied in the calculation of the ulcer area (UA) wherein the sum of small squares (4×1.8 = UA mm 2 ). The inhibition percentage (I %) was calculated by the following formula described in 17 with slight modifications: …”

Section: Gross Assessment Of Ulcermentioning

confidence: 99%

Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism

Taha¹,

Abdelwahab²,

Elsanousi³

et al. 2015

Phcog J

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Background: Sider (Ziziphus spina-christi (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. Aim of the study: The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. Materials and methods: Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95%ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). Conclusion: Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.

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“…The ulcer area was calculated as described by Kauffman and Grossman [7] . The inhibition percentage was calculated using the following formula [8] :…”

Section: Gross Gastric Lesions Evaluationmentioning

confidence: 99%

Gastroprotective Effects of Melastoma malabathricum Aqueous Leaf Extract against Ethanol-Induced Gastric Ulcer Iin Rats

Hussain¹,

Abdulla²,

Noor³

et al. 2008

American J. of Biochemistry and Biotechnology

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Abstract:The gastro-protective effects of the aqueous leaf extract of Melastoma malabathricum was investigated against ethanol-induced gastric mucosal injuries in rats. There were four groups of adult sprague dawley rats, consisting of six rats per group. Macroscopically, oral administration of absolute ethanol to rats that had been pre-treated with only distilled water significantly produced extensive lesions of the gastric mucosa. Oral pre-treatment with either 250 mg kg −1 of M. malabathricum extract, 500 mg kg −1 of M. malabathricum extract, or 20 mg kg −1 of omeprazole 60 minutes before administration of absolute ethanol significantly reduced the formation of gastric mucosal injuries. The observed protection was significant and dose dependent in inhibiting ethanol-induced gastric ulcers. Microscopically, rats that had been pre-treated with only distilled water showed marked damage of the gastric mucosa, induced submucosal edema and leucocytes infiltration. However, animals that had been pre-treated with aqueous leaf extracts or omeprazole showed marked reduction of gastric mucosal damage, reduction of oedema and less leucocyte infiltration of submucosal layer. The results indicated that 500 mg kg -1 aqueous leaf extract of M. malabathricum provided the best protection to the gastric mucosa in rats against ethanol-induced gastric ulcers.

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Methyl Angolensate: The Antiulcer Agent of the Stem Bark ofEntandrophragma angolense

Cited by 66 publications

References 2 publications

Synthesis of 2’-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats

Synthesis of 2’-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats

Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism

Gastroprotective Effects of Melastoma malabathricum Aqueous Leaf Extract against Ethanol-Induced Gastric Ulcer Iin Rats

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