Methyl aminolevulinate photodynamic therapy combined with curettage debulking for pigmented basal cell carcinoma

Gracia‐Cazaña, Tamara; González, Salvador; Juarranz, Ángeles; Gilaberte, Yolanda

doi:10.1111/phpp.12313

Cited by 6 publications

(5 citation statements)

References 12 publications

(9 reference statements)

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“…A Spanish group led by Garcia-Cazana presented a response rate in pBCCs treated with PDT of 76.19% [61]. These results were almost identical to nodular BCCs (76.8%), for which PDT is indicated.…”

Section: Pdt In Pbcc With Prior Debulking/curettagementioning

confidence: 84%

“…Abbreviations: ALA-aminolevulinic acid; MAL-methyl aminolevulinate; NS-not specified; PHD-purified hematoporphyrin derivatives; PS-photosensitizer. * After the second session with ALA-PDT, # a study by Garcia-Cazana et al [61] had no individual lesion/patient information, data included in this Table refers to the whole study population [62].…”

Section: Pdt In Pbcc Without Prior Debulkingmentioning

confidence: 99%

“…They treated 25 lesions (66.7% in head and neck area) with MAL-PDT. The session was preceded by curettage debulking, up to the point where the macroscopic pigment was completely removed [61].…”

Section: Pdt In Pbcc With Prior Debulking/curettagementioning

confidence: 99%

“…In 2017, Garcia-Cazana et al reported that BCC response to MAL-PDT was independent of age, sex, and both the size and location of the tumor. Although the difference was not statistically significant, the mean age of non-responders was higher, probably due to the age-associated decline in PpIX formation in human skin [61]. In 2019, the same group decided to identify potential biomarkers of BCC responses to MAL-PDT.…”

Section: Other Photodynamic Therapy Resistance Factors Of Basal Cell ...mentioning

confidence: 99%

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Photodynamic Therapy in Pigmented Basal Cell Carcinoma—A Review

Mazur,

Kwiatkowska,

Reich

2023

Biomedicines

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This review summarizes the effectiveness of photodynamic therapy (PDT) in the treatment of the pigmented subtype of basal cell carcinoma (BCC) based on the current literature. PDT is a light-activated treatment, non-invasive, that selectively destroys tumor cells and tissues via the interaction of a photosensitizer, light, and molecular oxygen. It can induce cancer cell death through direct tumor vascular damage or via the induction of immune response. However, human skin is also an absorption and scattering medium since it contains hemoglobin and melanin that act as chromophores. Eumelanin can be considered a light-absorber and an intracellular antioxidant that can neutralize PDT-induced ROS and, therefore, decrease PDT success. Various factors, including tumor depth, the degree of pigmentation in malignant cells, and the individual’s skin phototype, can impact the outcome of this intricate biochemical process. It has been widely recognized that PDT exhibits limited efficacy in the treatment of pigmented lesions. However, new combination techniques such as curettage or debulking before PDT show promising results in the treatment of pigmented BCC.

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Section: Pdt In Pbcc With Prior Debulking/curettagementioning

confidence: 84%

Section: Pdt In Pbcc Without Prior Debulkingmentioning

confidence: 99%

Section: Pdt In Pbcc With Prior Debulking/curettagementioning

confidence: 99%

Section: Other Photodynamic Therapy Resistance Factors Of Basal Cell ...mentioning

confidence: 99%

See 2 more Smart Citations

Photodynamic Therapy in Pigmented Basal Cell Carcinoma—A Review

Mazur,

Kwiatkowska,

Reich

2023

Biomedicines

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show abstract

“…Dermoscopy could help identify structures typical of pigmented BCCs and improve the response to PDT of BCCs with pigmented structures prior to curettage or debulking ( 6 ), thus achieving greater efficacy.…”

Section: Discussionmentioning

confidence: 99%