The application of physical pretreatment in photodynamic therapy for skin diseases

Liu, Dihui; Li, Jinmao; Chen, Mingliang; Wu, Lisha

doi:10.1007/s10103-020-03233-6

Cited by 16 publications

(6 citation statements)

References 52 publications

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“…PDT provides many advantages, including being less invasive, reproducible and less likely to cause tissue defects and dysfunction. But reports on the efficacy of PDT for different diseases are not very consistent, which might be due to inadequate penetration of photosensitizers through tissue [21]. A growing number of studies suggest that the thickness of the lesion may affect the efficacy of PDT.…”

Section: Discussionmentioning

confidence: 99%

Superficial shaving combined with photodynamic therapy is effective as a treatment for condyloma acuminatum

Pan

Chen

2022

Transl Biophotonics

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Condyloma acuminatum is a common sexually transmitted disease caused by human papillomavirus. Its prevalence and recurrence rates are high. While there are multiple treatment options for condyloma acuminatum, no single therapy form is effective in achieving complete remission. Photodynamic therapy (PDT) was shown to be very promising as a treatment option for condyloma acuminatum. However, for some patients the therapeutic result after a single PDT session is not satisfactory. Thus, it is necessary to develop an effective treatment method for recalcitrant condyloma acuminatum. We hypothesize that suboptimal therapeutic results after a single PDT may be caused by an insufficient penetration of the photosensitizer into the tissue. Here, we applied a combination of superficial shaving and PDT to address this issue. All patients were satisfied with the effect of the treatment, and their quality of life improved significantly. Pain was the major adverse event during treatment but was acceptable to all patients. Therefore, superficial shaving in combination with PDT is safe and effective.

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Section: Discussionmentioning

confidence: 99%

Superficial shaving combined with photodynamic therapy is effective as a treatment for condyloma acuminatum

Pan

Chen

2022

Transl Biophotonics

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“…Several studies also showed the efficacy of pre-treatments before topical PDT procedures using several techniques such as curettage, superficial shaving, laser, surgical resection, plum-blossom needles, and microneedles. These pre-treatments were associated with improved efficacy and reduced recurrence in several reports [6], [7], [8].…”

Section: Topical Pdtmentioning

confidence: 92%

The Efficacy of Topical Photodynamic Therapy in Precancerous Lesions of the Skin: A Literature Review

Putra

Jusuf

Theresia

2022

Open Access Maced J Med Sci

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Precancerous skin lesions are associated with high probability of malignant transformation to squamous cell carcinoma. Early detection and management are necessary to improve prognosis and outcomes. Literatures showed that topical photodynamic therapy (PDT) is a promising treatment method which can be successfully applied in several conditions in dermatology. This study aims to review the efficacy of topical PDT for various precancerous lesions in dermatology, such as actinic keratosis, Bowen disease, and Bowenoid papulosis.

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“…channel (Yu et al 1992). This natural product has also been added to medicines to treat allergic skin diseases as it induces Th1 type cells to produce IFN-c (Lu et al 2021). When fraxinellone ( 24) was administered to mice with passive skin allergy at a concentration of 100 mg/kg, the inhibition rate of skin mast cell degranulation reached 62.5% (Lu et al 2021).…”

Section: Other Biological Activitiesmentioning

confidence: 99%

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

et al. 2023

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Phytochemical studies on the roots, twigs and leaves of Meliaceae and Rutaceae family plants have revealed the presence of non-complex terpenes derived from limonoid fragmentation. The occurrence and chemical structure of these degraded limonoids isolated from 1930 to March 2022 are reported in this review. Particular attention is given to the degradation levels in these compounds and their absolute configuration to discover presumable deconstruction pathways from more complex limonoids. Plausible intermediates have been postulated for most of them that would explain their origin from limonoids. The total or semi-synthesis of the most isolated degraded limonoids or analogues remains undescribed. This review focuses on the bioactivity of these fragmented limonoids and their synthesized analogues. Based on pharmacological and agrochemical studies, degraded limonoids appear to be excellent structural leads to consider for the total or semi-synthesis of more potent derivatives with the aim of discovering new hits and clarifying their modes of action.

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The application of physical pretreatment in photodynamic therapy for skin diseases

Cited by 16 publications

References 52 publications

Superficial shaving combined with photodynamic therapy is effective as a treatment for condyloma acuminatum

Superficial shaving combined with photodynamic therapy is effective as a treatment for condyloma acuminatum

The Efficacy of Topical Photodynamic Therapy in Precancerous Lesions of the Skin: A Literature Review

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

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