Methyclothiazide: a hydrogen-bonded layer structure

Abstract

In the title compound, C9H11Cl2N3O4S2, systematic name 6-chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, three kinds of N—H...O hydrogen bond generate a sheet structure. The combination of four N—H...O hydrogen bonds yields an R 4 4(26) ring, with adjacent rings linked into two-dimensional layers parallel to the (001) plane. Pairs of adjacent planes are further connected by N—H...O hydrogen bonds.

Polythiazide

“…For a preliminary crystallographic study at room temperature, see Dupont & Dideberg (1970). For crystal structures of polymorphs and solvates of related thiazide compounds, see: Zhou et al (2006); Johnston et al (2007a,b); Johnston et al (2007); Fernandes, Florence et al (2006); ; Johnston et al (2008); Fabbiani et al (2007); ; .…”