1993
DOI: 10.1016/s0015-0282(16)55858-0
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Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control

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Cited by 98 publications
(49 citation statements)
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“…19 Furthermore, subsequent fertility after local MTX injection was satisfactory. 13,20 Therefore, local administration of MTX (50 mg) was thought to have no toxicity in the tube. Administration of prophylactic MTX to all patients remains a controversial issue.…”
Section: Discussionmentioning
confidence: 99%
“…19 Furthermore, subsequent fertility after local MTX injection was satisfactory. 13,20 Therefore, local administration of MTX (50 mg) was thought to have no toxicity in the tube. Administration of prophylactic MTX to all patients remains a controversial issue.…”
Section: Discussionmentioning
confidence: 99%
“…Efforts to attain maximal efficacy and minimize adverse effects of systemic MTX resulted in various protocols for local medical treatment administered into the gestational sac transvaginally under sonographic or under laparoscopic guidance. Drugs that have been used for local treatment are methotrexate 1mg/kg (Feichtinger, Kemeter, 1987;Pansky, Bubowski, 1989;Fernandez et al, 1993), KCL, prostaglandins, and hyperosmolar glucose. Feichtinger and Kemeter (1987) described the first case where local treatment with MTX was administered into the gestational sac transvaginally under sonographic.…”
Section: Local Treatmentmentioning
confidence: 99%
“…Several doses of MTX have been described (Benifla et al, 1996;Sagiv et al, 2001;Lin et al, 2007). The most used is a dose of 1 mg/kg body weight and this is the dose selected for the study (Fernandez et al, 1993)). However, other doses including 100 mg single dose (Lin et al, 2007), 50mg/m 2 body surface (Lim et al, 2007) and an unadjusted dose of 12.5 mg have been used (Sagiv et al, 2001).…”
Section: Selection Criteriamentioning
confidence: 99%
“…En años más recientes, se introdujo la dosis única minimizando efectos secundarios y costos (17,18). Existen varias publicaciones de protocolos experimentales para el tratamiento local, administrando en el saco gestacional por vía transvaginal bajo guía ecográfica o laparoscópica, metotrexato (19,20), prostaglandinas (21,22) o glucosa hiperosmolar (23).…”
Section: Introductionunclassified