Methotrexate Loaded Solid Lipid Nanoparticles (SLN) for Effective Treatment of Carcinoma

Ruckmani, K.; Sivakumar, M.; Pa, Ganeshkumar

doi:10.1166/jnn.2006.457

Cited by 64 publications

(32 citation statements)

References 10 publications

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“…Tumour targetinghas been achieved with SLNs loaded with drugs like methotrexate [23] and Camptothecin [24].Tamoxifen an anticancer drug is incorporated inSLN to prolong release of drug after i.v.…”

Section: Slns As a Targeted Carrier For Anticancer Drugto Solid Tumorsmentioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

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Section: Slns As a Targeted Carrier For Anticancer Drugto Solid Tumorsmentioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

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“…Nanostructured lipid carriers (NLC), composed of a solid lipid matrix with a certain content of a liquid lipid phase, are another generation of SLN [7] . SLN and NLC may overcome the problems of membrane stability and drug leaching associated with liposomes and conventional emulsions [8] .…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion

Huang

Hua

Yang³

et al. 2008

Acta Pharmacologica Sinica

172

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Aim: Camptothecin is an anticancer drug that acts against a broad spectrum of tumors. The clinical application of camptothecin is limited by its insolubility, instability, and toxicity problems. The aim of this study was to develop and characterize lipid nanoparticles with different lipid cores which can circumvent these problems. Methods: Lipid nanoparticles made of Precirol (solid lipid nanoparticles; SLN-P), Compritol (SLN-C), Precirol+squalene (nanostructured lipid carriers; NLC), and squalene (a lipid emulsion; LE) as the lipid core material were prepared. These systems were assessed and compared by evaluating the mean diameter, surface charge, molecular environment, camptothecin release, and cell viability against a melanoma. The safety and storage stability of these systems were also preliminarily examined. Results: The particle size ranged from 190 to 310 nm, with the NLC and LE showing the smallest and largest sizes, respectively. The in vitro drug release occurred in a sustained manner in decreasing order as follows: LE>NLC>SLN-P>SLN-C. It was found that varying the type of inner phase had profound effects on cell viability. The SLN-P generally showed higher cytotoxicity than the free control. The treatment of melanomas with the camptothecin-loaded SLN-C and NLC yielded cytotoxicity comparable to that of the free form. The percentage of erythrocyte hemolysis by all nanoparticles was ≤5%, suggesting a good tolerance to lipid nanoparticles. Conclusion: The results collectively suggest that the SLN-P may have the potential to serve as a delivery system for parenteral camptothecin administration because of the sustained drug release, strong cytotoxicity, limited hemolysis, and good storage stability. Key wordscamptothecin; solid lipid nanoparticle; nanostructured lipid carrier; lipid emulsion; drug delivery; melanoma 4 Correspondence to Prof Jia-you FANG.Phn 886-3-211-8800, ext 5521.

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“…Reproducibility was more than ultrasonication method but lesser than that of solvent emulsification evaporation method 23 .…”

Section: Melting Dispersion Techniquementioning

confidence: 86%

Untitled

2018

IJPSR

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Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles in the nanometer size range, which are dispersed in water or in an aqueous surfactant solution. SLN technology represents a promising new approach to deliver hydrophilic as well as lipophilic drugs. Due to their unique size dependant properly, lipid nanoparticles offer to devlop the new therapeutics. Method: The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for several levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site-specific drug delivery and hence have attracted the wide attention of researchers. Conclusion: The present review article focus on overview about the potential advantages, disadvantages, the excipients and all the different methods involved in their production methodology, Characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases. Special attention is given to models of drug incorporation in SLN and the release pattern of SLN. INTRODUCTION:The field of Novel Drug Delivery System is emerging at an exponential rate with the deep understanding gained in diversified fields of Biotechnology, Biomedical Engineering and Nanotechnology 1 . Nanotechnology is a newer development technology expected to bring revolutionary changes in the field of life sciences. Nanotechnology, as defined by the National Nanotechnology Initiative (NNI), is the study and use of structures roughly in the size range of 1 -100 nm.

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Methotrexate Loaded Solid Lipid Nanoparticles (SLN) for Effective Treatment of Carcinoma

Cited by 64 publications

References 10 publications

Solid Lipid Nanoparticle: A Review

Solid Lipid Nanoparticle: A Review

Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion

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