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Abstract

Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles in the nanometer size range, which are dispersed in water or in an aqueous surfactant solution. SLN technology represents a promising new approach to deliver hydrophilic as well as lipophilic drugs. Due to their unique size dependant properly, lipid nanoparticles offer to devlop the new therapeutics. Method: The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for several levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site-specific drug delivery and hence have attracted the wide attention of researchers. Conclusion: The present review article focus on overview about the potential advantages, disadvantages, the excipients and all the different methods involved in their production methodology, Characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases. Special attention is given to models of drug incorporation in SLN and the release pattern of SLN. INTRODUCTION:The field of Novel Drug Delivery System is emerging at an exponential rate with the deep understanding gained in diversified fields of Biotechnology, Biomedical Engineering and Nanotechnology 1 . Nanotechnology is a newer development technology expected to bring revolutionary changes in the field of life sciences. Nanotechnology, as defined by the National Nanotechnology Initiative (NNI), is the study and use of structures roughly in the size range of 1 -100 nm.

A Systematic Review on Nano Drug Delivery System: Solid Lipid Nanoparticles (Sln)

“…SLNs are densely packed lipid matrix networks (perfect crystalline structure) with little room for drug encapsulation, resulting in low drug loading capacity [10][11][12][13]. A variety of factors influence drug loading or encapsulation in SLNs, including drug-lipid melt interaction, the composition or state of the lipid matrix, drug miscibility with the lipid matrix, and the drug being distributed or dissolved in the lipid matrix.…”

“…The tailored drug delivery systems are either directed at a specific place or are designed for a controlled dispensing of therapeutic substances at that location. Their development involves self-assembly, in which well-defined shapes or patterns emerge spontaneously from building blocks [12].…”