Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer

Fathi, Marziyeh; Barar, Jaleh; Erfan-Niya, Hamid; Omidi, Yadollah

doi:10.1016/j.ijbiomac.2019.10.272

Cited by 57 publications

(26 citation statements)

References 50 publications

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“…It can be used as a promising antioxidant material for drug delivery and tissue engineering. Based on chitosan, Fathi et al [53] designed methotrexate-conjugated multifunctional nanoparticles for targeted delivery of erlotinib, which has potential application in targeted therapy of ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Quan

Kong

et al. 2021

Molecules

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Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.

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Section: Introductionmentioning

confidence: 99%

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Quan

Kong

et al. 2021

Molecules

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“…The double-sensitive in situ hydrogel is formed by grafting polymerization of the two sensitive polymers or connecting them with an interpenetrating network, where each polymer chain also independently has different stimulus response (Norouzi et al, 2016;Wang et al, 2017;Fathi et al, 2019). The dual sensitive in-situ hydrogels, such as temperature-pH, temperature-ion or pH-magnetic field sensitive in-situ hydrogel, not only retain the responsiveness of single sensitive hydrogel, but also have complementary effects on different combinations of them, thus have great potential for increasing applications in various areas.…”

Section: Dual Sensitive In Situ Hydrogelmentioning

confidence: 99%

Research progress in the application of in situ hydrogel system in tumor treatment

Wei

Yin

et al. 2020

Drug Delivery

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The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment. ARTICLE HISTORY

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“…For a compound to be used in a drug delivery system, it must present biocompatibility, low immunogenicity, and low toxicity. Furthermore, it is also relevant that it can be modified [132,140,141]. These properties are widely observed in marine-derived natural polymers such as carrageenan, fucoidans, alginate, and agar, making them potential bases for producing these systems [142].…”

Section: Advantages and Applications Of Various Marine-derived Compoumentioning

confidence: 99%

“…Chitosan nanoparticles were also used to encapsulate Methotrexate and Dexamethasone and showed promising results in controlling inflammation in a rat arthritic model after intraperitoneal administration [152]. Other Methotrexate conjugated nanoparticles were engineered based on chitosan and demonstrated the potential for treating ovarian cancer [140]. Another complex sialic acid (SA)-modified chitosan oligosaccharide-based biphasic calcium phosphate (BCP) loaded with Methotrexate not only was capable of a targeted delivery into arthritic paws but executed a rapid drug release and significantly inhibited the inflammation response.…”

Section: Advantages and Applications Of Various Marine-derived Compoumentioning

confidence: 99%

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with a prevalence rate of up to 1% and is significantly considered a common worldwide public health concern. Commercially, several traditional formulations are available to treat RA to some extent. However, these synthetic compounds exert toxicity and considerable side effects even at lower therapeutic concentrations. Considering the above-mentioned critiques, research is underway around the world in finding and exploiting potential alternatives. For instance, marine-derived biologically active compounds have gained much interest and are thus being extensively utilized to confront the confines of in practice counterparts, which have become ineffective for 21st-century medical settings. The utilization of naturally available bioactive compounds and their derivatives can minimize these synthetic compounds’ problems to treat RA. Several marine-derived compounds exhibit anti-inflammatory and antioxidant properties and can be effectively used for therapeutic purposes against RA. The results of several studies ensured that the extraction of biologically active compounds from marine sources could provide a new and safe source for drug development against RA. Finally, current challenges, gaps, and future perspectives have been included in this review.

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Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer

Cited by 57 publications

References 50 publications

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Research progress in the application of in situ hydrogel system in tumor treatment

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

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