Methohexitone-Induced Convulsions in Epileptics

Cg, Male; Allen, EM

doi:10.1177/0310057x7700500307

Cited by 11 publications

(2 citation statements)

References 20 publications

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“…anaesthetics studied so far. They vary from small involuntary muscle movements, seen also with thiopentone but more so with the methylated barbiturates, to true convulsions as described by Goldman (1965), Uppington (1973) and Male and Allen (1977). Hypertonus is a related variant, especially with ketamine.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Three Preparations of Etomidate

Zacharias¹,

Clarke²,

Dundee³

et al. 1978

British Journal of Anaesthesia

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Three formulations of etomidate were evaluated in unpremedicated patients undergoing minor gynaecological procedures. There was a high frequency of pain on injection (up to 50%) and excitatory phenomena (up to 95%) with all formulations. The frequency of excitatory phenomena was significantly greater than that after methohexitone. Recovery was rapid, but emetic sequelae were frequent and significantly more marked than after methohexitone.

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Section: Discussionmentioning

confidence: 98%

Evaluation of Three Preparations of Etomidate

Zacharias¹,

Clarke²,

Dundee³

et al. 1978

British Journal of Anaesthesia

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“…The convulsant/anti-convulsant properties of different anaesthetics are of clinical importance and of mechanistic interest. For example, much has been written for and against the use of Althesin, ketamine and methohexitone in patients with status epilepticus [1][2][3]. However, less is known about anaesthetic interactions with chemicallyinduced convulsions, and there have been relatively few systematic comparative studies.…”

Section: B Wardley-smith H J Little and M J Halseymentioning

confidence: 99%

Lack of Correlation Between the Anaesthetic and Anti-Convulsant Potencies of Althesin, Ketamine and Methohexitone

Wardley‐Smith¹,

Little²,

Halsey³

1988

British Journal of Anaesthesia

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Using Sprague-Dawley rats, the anti-convulsant potencies of Althesin, ketamine and methohexitone were determined for bicuculline-and strychnine-induced seizures and compared with their effects on hyperbaric seizures. All three anaesthetics protected against both types of chemical convulsants; the degree of protection varied from 34 to 151%, with Althesin being the most effective. However, there was no correlation between their anti-convulsant and anaesthetic potencies, and no relationship between the effects on chemical convulsions and the interactions of the same agents with hyperbaric convulsions. These data suggest that the order of anti-convulsant potencies at equivalent anaesthetic concentration is Althesin much greater than ketamine = methohexitone, and that neither bicuculline-nor strychnine-induced seizures are a good model for hyperbaric convulsions.

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