Methohexital Sedation of Children Undergoing CT Scan

Varner, Pamela D.; Ebert, John P.; McKay, Robert D.; Nail, Carolyn S.; Whitlock, Theresa M.

doi:10.1213/00000539-198506000-00014

Cited by 24 publications

(8 citation statements)

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“…Our study results are similar to those of Varner et al, 12 who used intramuscular MXT in a dose of 10 mg/kg and found that this offered adequate sedation in 92% of their patients. Their onset was faster (3.3 minutes) but their duration of action was slightly longer (86 minutes).…”

Section: Discussion Significancesupporting

confidence: 91%

Rectal Methohexital Sedation for Computed Tomography Imaging of Stable Pediatric Emergency Department Patients

et al. 2000

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Rectal MXT compares favorably to other methods of nonintravenous sedation for CT scanning of stable pediatric ED patients in terms of rapidity of onset and reliability but does cause a significant amount of transient respiratory depression. Its use requires careful monitoring of oxygen saturation and should be used only in a setting where physicians skilled in airway management are present. If these requirements are met, it may be a good choice for the relatively noninvasive sedation of pediatric ED patients undergoing painless but anxiety-provoking procedures.methohexital, pediatric procedure sedation, rectal administration, computerized tomography imaging.

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Section: Discussion Significancesupporting

confidence: 91%

Rectal Methohexital Sedation for Computed Tomography Imaging of Stable Pediatric Emergency Department Patients

et al. 2000

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“…All children had fallen asleep after administration of the induction dose. In contrast, sedation failure is described in 3-15 percent of cases when other drugs, administered as single bolus, are used for sedation for radiological procedures (3,9,10).…”

Section: Discussionmentioning

confidence: 99%

Deep sedation with propofol in preschool children undergoing radiation therapy

Scheiber

Ribeiro

Karpienski

et al. 1996

Pediatric Anesthesia

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Immobilization of children undergoing radiation therapy always requires anaesthesia. Deep sedation with continuous infusion of propofol and spontaneous breathing, (we call it ¿sedative anaesthesia'), may be an alternative to general anaesthesia with intubation and controlled ventilation. This clinical report deals with 155 anaesthetics performed in 11 consecutive paediatric oncology patients, mean age 30 months (range 19-42), who required radiation therapy for from seven to 33 consecutive days. Mean duration of anaesthesia was 18 ( +/- 11) mins. For induction, a loading dose of 3.6 (SD +/- 0.59) mg.kg-1 propofol was administered immediately followed by a continuous infusion of 7.4 ( +/- 2.2) mg.kg-1.h-1 for maintenance of anaesthesia. There were no complications of clinical importance involving respiration, circulation or neurology, except for one short episode of transient desaturation, which was managed by suctioning and changing head position. Children opened their eyes spontaneously four ( +/- 3.7) min after discontinuing the propofol infusion and could be discharged about 30 mins later. Tachyphylaxis or unpleasant side effects during and after anesthesia have not been observed. Sedative anaesthesia with propofol seems to be an excellent method to immobilize paediatric patients during radiotherapeutic procedures.

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“…Most have involved MTX administered per rectum for CT sedation. 11,22,23 This study suggests that MTX is superior to PTB for sedating pediatric ED patients for head CT. This study's findings are consistent with another study 12 of IV MTX for PED sedation.…”

Section: Discussionmentioning

confidence: 78%