CHRISTNIAS DISEASE BRITISH MEDICAL JOURNAL grossly reduced because of the deficiency in the blood of a factor called the Christmas factor. The Christmas factor can be obtained most readily from serum, and in some features resembles the serum factor VII of Koller et al. (1951). It differs greatly from the antihaemophilic globulin, and the blood from patients with true haemophilia (antihaemophilic globulin deficiency) is as effective as is normal blood in correcting the clotting abnormality in the blood or plasma of patients with Christmas disease. In the treatment of haemorrhage in cases of Christmas disease concentrated preparations of antihaemophilic globulin are ineffective.
Treatment of fresh sera with polyethylene glycol 6000 at a final concentration of 100 g/l produced selective precipitation of low-density lipoproteins with only traces of contamination with high-density lipoproteins, as determined by electroimmunoassay using antisera to human alpha1-lipoprotein and human beta-lipoprotein. Supernatants collected for high-density lipoprotein-cholesterol estimation were free from low-density lipoproteins. Precipitates sedimented readily from specimens with high triglyceride contents, and secondary precipitation during enzymatic cholesterol determinations was absent. Values obtained by this method correlated well with those obtained by precipitation of low-density lipoproteins with heparin and manganous ions at concentrations optimal for discrete of lipoprotein classes (r = 0.975; p less than 0.001).
Rectal MXT compares favorably to other methods of nonintravenous sedation for CT scanning of stable pediatric ED patients in terms of rapidity of onset and reliability but does cause a significant amount of transient respiratory depression. Its use requires careful monitoring of oxygen saturation and should be used only in a setting where physicians skilled in airway management are present. If these requirements are met, it may be a good choice for the relatively noninvasive sedation of pediatric ED patients undergoing painless but anxiety-provoking procedures.methohexital, pediatric procedure sedation, rectal administration, computerized tomography imaging.
Plasma catecholamine concentrations were estimated in a group of 17 fasting patients immediately before and 3 days after cardiac catheterisation. At both times electrocardiograms were recorded and blood pressures, heart rates, and respiration rates measured. Control catecholamine values were established in a group of 10 male and 10 female volunteers, bled at the same time of day under the same conditions of nutrition and posture. Levels of adrenaline and noradrenaline were increased substantially before catheterisation; 3 days later, the values were comparable to those of the controlgroup, though still marginally higher. The increments in catecholamine levels were independent of sex and of the presence or otherwise ofpersistent supraventricular arrhythmias. In spite of the considerably raised catecholamine levels, electrocardiographic patterns remained unchanged, as did the other physiological values. The absence of any relation between enhanced catecholamine secretion and physiological effects is considered to be the result either of enhanced parasympathetic activity or of adaptation to a prolonged period of stress.The close links between the sympathoadrenal investigations of the interrelation between stress system and the metabolic consequences of stress and arrhythmia promotion in subjects free from have been exemplified by the increased catechola-acute clinical conditions has been confined to mine excretions observed under different condi-short-term stress situations (Carlson et al., 1968; tions, including apprehension and uncertainty Taggart et al., 1972Taggart et al., , 1973.
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