Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

Abstract

This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

“…These results showed that CUNPs were more toxic than Cu 2+ because of the generation of ROS, DNA damage, and decreased levels of reduced glutathione (GSH) compared with those of control cells. The mechanism of toxicity of CUNPs in the cellular membrane was suggested by Grigore et al through a mechanism similar to those of Trojan horse‐type. If these nanoparticles are soluble, they can penetrate the membrane via cancelling the membrane barrier function.…”

“…Recently, several studies have been established to prove their potentials in biomedical field using in vitro and in vivo models . In literatures, the copper nanoparticles are synthesized by some important methods, such as electrochemical techniques, photochemical reduction, chemical reduction, thermal decomposition, laser ablation, and green synthesis …”

The roles of nanotechnology and internet of nano things in healthcare transformation

“…Likewise, silver nanoparticles show positive effects in various wound treatments (e.g., burns, chronic ulcers, toxic epidermal necrolysis, and pemphigus) which mainly consists in significantly shorter woundhealing time [16]. Copper oxide nanoparticles also show antimicrobial ability, which implies their application in disinfecting surfaces and medical devices as well as antimicrobial wound dressings, textiles and coatings [13]. Silver nanoparticles can be used for drug delivery of therapeutic agents in eye care for coating contact lenses [15].…”

“…New and enhanced properties and functionalities are the results of production of novel nanomaterials and nanodevices. This means that the new ways to synthesize nanoparticles and create nanomaterials [6]- [20], the analysis of nanoparticles' and nanomaterials' potential toxicity [12], [20]- [30], the development of novel nanodevices, nanosensors and nanocommunication [13], [18], [20], [31]- [35], and the implementation of green practices in nanotechnology and the IoNT [11], [24], [36]- [41] are some of the current most interesting topics to research. The particular interest in nanotechnology and the IoNT consists in the fact that they have opened a whole new world of potential remarkable improvements in medicine and healthcare.…”

Collagen-Nanoparticles Composites for Wound Healing and Infection Control

“…Although the specific mechanism of the antimicrobial effect related to the use of CuO NPs is not fully known, it has been reported that the generation of reactive oxygen species (ROS) within bacterial cells is enhanced when using CuO-water suspensions [62,63].…”