Methods of assessment of selenium status in humans: a systematic review

Ashton, Kate; Hooper, Lee; Harvey, Linda J.; Hurst, Rachel; Casgrain, Amélie; Fairweather‐Tait, Susan J.

doi:10.3945/ajcn.2009.27230f

Cited by 254 publications

(232 citation statements)

References 65 publications

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“…Correlation between dietary measurements and selenium biomarkers (whole blood and plasma) were modest (r = 0.1 to 0. Regarding biomarkers for selenium measurement, Ashton 2009 showed in a systematic review that plasma and whole-blood selenium concentrations increased with higher selenium intake in supplementation studies. Although Ashton 2009 could not identify serum studies for this systematic review, plasma, whole-blood and presumably serum selenium levels were considered by the authors to adequately reflect a short-term increase in supplemental selenium intake in healthy adults.…”

Section: Selenium Measurement and Categorical Exposure Classificationmentioning

confidence: 99%

Selenium for preventing cancer

Dennert¹,

Zwahlen

Brinkman

et al. 2018

Cochrane Database of Systematic Reviews

276

184

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Section: Selenium Measurement and Categorical Exposure Classificationmentioning

confidence: 99%

Selenium for preventing cancer

Dennert¹,

Zwahlen

Brinkman

et al. 2018

Cochrane Database of Systematic Reviews

276

184

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“…Mean status marker level (or median where indicated) SD Serum folate (mean and SD/median; nmol/l) Croatia (53) 100 F 20-30 23 9 Czech Republic (lactation) (58) (20)(21)(22)(23)(24)(25)(26)(27)(30)(31)(32)(33) : serum folate 10 nmol/l for adults; urinary iodine 100 mg/l for adults, 150 mg/l for pregnant women; Hb 130 g/l for males, 120 g/l for females, 110 g/l for pregnant women; serum vitamin B 12 150 pmol/l for adults; serum Zn 10 mmol/l for children and females, 10?7 mmol/l for males.…”

Section: Countrymentioning

confidence: 99%

“…Relevant ANR are given in the figure captions. To assess adequacy of levels of status markers, we used guidance on cut-off values from EURRECA experts (30)(31)(32)(33) . These cut-off values were based on key references mostly published by the WHO in cooperation with other institutions (20)(21)(22)(23)(24)(25)(26)(27) .…”

Section: Data Analysesmentioning

confidence: 99%

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Novaković

Cavelaars

Bekkering

et al. 2012

Public Health Nutr.

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Objective: To compare micronutrient intakes and status in Central and Eastern Europe (CEE) with those in other European countries and with reference values. Design: Review of the micronutrient intake/status data from open access and grey literature sources from CEE. Setting: Micronutrients studied were folate, iodine, Fe, vitamin B 12 and Zn (for intake and status) and Ca, Cu, Se, vitamin C and vitamin D (for intake). Intake data were based on validated dietary assessment methods; mean intakes were compared with average nutrient requirements set by the Nordic countries or the US Institute of Medicine. Nutritional status was assessed using the status biomarkers and cut-off levels recommended primarily by the WHO. Subjects: For all population groups in CEE, the mean intake and mean/median status levels were compared between countries and regions: CEE, Scandinavia, Western Europe and Mediterranean. Results: Mean micronutrient intakes of adults in the CEE region were in the same range as those from other European regions, with exception of Ca (lower in CEE). CEE children and adolescents had poorer iodine status, and intakes of Ca, folate and vitamin D were below the reference values. Conclusions: CEE countries are lacking comparable studies on micronutrient intake/ status across all age ranges, especially in children. Available evidence showed no differences in micronutrient intake/status in CEE populations in comparison with other European regions, except for Ca intake in adults and iodine and Fe status in children. The identified knowledge gaps urge further research on micronutrient intake/status of CEE populations to make a basis for evidence-based nutrition policy.

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“…Blood selenium concentration has been accepted as a useful biomarker of selenium status and intake and is the most widely used method in research [36]. However, both dietary intake and plasma selenium have been associated with daily urinary excretion especially in populations that live in selenium-deficient areas and urine can be used to assess recent selenium intake [20].…”

Section: Open Access Fnsmentioning

confidence: 99%

Iodine and Selenium Intake in a Sample of Women of Childbearing Age in Palmerston North, New Zealand after Mandatory Fortification of Bread with Iodised Salt

Shukri¹,

Coad²,

Weber³

et al. 2014

FNS

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Iodine deficiency is a worldwide public health problem, which has long been observed in many parts of the world, including New Zealand (NZ). The aim of this study was to assess iodine and selenium intake among women of childbearing age in Palmerston North, New Zealand post mandatory fortification of bread with iodised salt. Fifty women of childbearing age completed a researcher-led questionnaire, including a semi-quantitative food frequency questionnaire. Iodine and selenium were analysed in 24-hour urine samples. The median urinary iodine concentration (UIC) was 65 µg/l with 30% below 50 µg/l; representing mild iodine deficiency according to the World Health Organization. The estimated median daily iodine intake (130 µg/day) was higher than the Estimated Average Requirement (100 µg/day) and higher than seen in women prior to fortification. The median excretion of selenium (32 µg/day) was slightly above level suggested as adequate (30 µg/day) and estimated median intake (57 µg/day) was higher than Estimated Average Requirement (50 µg/day). Selenium and iodine excretion were significantly correlated (Spearman's rank order; r(50) = 0.547, p < 0.001). The major contributors to iodine intake were milk (36%), bread (25%) and fish/seafood (15%). Participants had a mean intake of 2.5 slices of bread/day, which contributed approximately 14 to 20 µg of iodine. The majority of participants (74%) had iodised salt at home, but less than half (48%) used iodised salt exclusively. In conclusion, despite the mandatory fortification of bread with iodised salt in NZ, UIC of the study population indicates iodine deficiency although their estimated dietary intakes appear adequate. It is essential that government initiatives to improve iodine status are evaluated for their efficacy.

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Methods of assessment of selenium status in humans: a systematic review

Abstract: For all potentially useful biomarkers, more information is needed to evaluate their strengths and limitations in different population groups, including the effects of varying intakes, the duration of intervention, baseline selenium status, and possible confounding effects of genotype.

Cited by 254 publications

References 65 publications

Selenium for preventing cancer

Selenium for preventing cancer

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Iodine and Selenium Intake in a Sample of Women of Childbearing Age in Palmerston North, New Zealand after Mandatory Fortification of Bread with Iodised Salt

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