Methods for wastewater treatment

Khan, Mariam; Khan, Safia

doi:10.1016/b978-0-12-823551-5.00011-2

Cited by 1 publication

(1 citation statement)

References 176 publications

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“…[24,[28][29][30][31] One such scaffold system, the sodium alginate hydrogel (SAH), has become popular due to its biocompatibility and ability to promote tissue healing and regeneration. [32][33][34][35][36][37] SAH is similar in composition to extracellular matrix components and has a mild gel process that does not negatively impact the cell membrane structure. [38] Notably, wrapping rodent embryos with 3.0% sodium alginate did not harm embryonic development, implantation rate, or fetal development, showing good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Decidual Stromal Cells Derived Exosomes in Sodium Alginate Hydrogel as an Innovative Therapeutic Strategy for Advancing Endometrial Regeneration and Reinstating Fertility

Liang,

Shuai,

Zhang

et al. 2024

Adv Healthcare Materials

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Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, in severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation and tumorigenicity limit its use. Exosomes, more stable and immunogenicity‐reduced than parent cells, have emerged as a promising avenue for IUA treatment. In this study, a novel approach has been proposed wherein exosomes originating from decidual stromal cells are encapsulated within sodium alginate hydrogel (SAH) scaffolds to repair endometrial damage and restore fertility in a mouse IUA model. Current results demonstrate that in situ injection of decidual stromal cell‐derived exosomes (DSC‐exos)/SAH into the uterine cavity has the capability to induce uterine angiogenesis, initiate mesenchymal‐to‐epithelial transformation (MET), facilitate collagen fiber remodeling and dissolution, promote endometrial regeneration, enhance endometrial receptivity and contribute to the recovery of fertility. RNA sequencing and advanced bioinformatics analysis reveal miRNA enrichment in exosomes, potentially supporting endometrial repair. This finding elucidates how DSC‐exos/SAH mechanistically fosters collagen ablation, endometrium regeneration, and fertility recovery, holding the potential to introduce a novel IUA treatment and offering invaluable insights into the realm of regenerative medicine.This article is protected by copyright. All rights reserved

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