Methods for the Chemical Analysis of Degradable Synthetic Polymeric Biomaterials

Ghaffar, Abdul; Schoenmakers, Peter J.; Wal, Sj. van der

doi:10.1080/10408347.2013.831729

Cited by 16 publications

(6 citation statements)

References 111 publications

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“…1-4 The applications of biodegradable films and hydrogels are emerging in the area of drug delivery and tissue engineering due to their biocompatible and non-toxic nature. 5-13…”

Section: Introductionmentioning

confidence: 99%

“…SA is usually obtained from marine brown algae. 14 It has been widely used in controlled drug delivery and pharmaceutical dosage materials due to their biocompatible, biodegradable, 13 high mechanical strength, and high hydrophilic nature. 15 It was investigated that SA based microspheres were used for drug delivery applications due to their flexibility in size, shape and their ability to entrap cells as well as biomolecules.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] The applications of biodegradable films and hydrogels are emerging in the area of drug delivery and tissue engineering due to their biocompatible and non-toxic nature. [5][6][7][8][9][10][11][12][13] Sodium alginate (SA), a natural polysaccharide, consists of a linear chain of (1,3)-a-D-guluronic acid and (1,4)-b-Dmannuronic acid. SA is usually obtained from marine brown algae.…”

Section: Introductionmentioning

confidence: 99%

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Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

Sarwar

Ghaffar

Huang

2021

Polymers and Polymer Composites

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Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

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“…1-4 The applications of biodegradable films and hydrogels are emerging in the area of drug delivery and tissue engineering due to their biocompatible and non-toxic nature. 5-13…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

Sarwar

Ghaffar

Huang

2021

Polymers and Polymer Composites

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“…In continuation of our efforts to develop materials for controlled drug delivery [48,49], the purpose of the current study was to develop a smart drug delivery system for ciprofloxacin hydrochloride monohydrate (CPX) using biodegradable CS/PAH blend films. CS and PAH were selected to prepare a series of blend films with different compositions as smart drug delivery matrices.…”

Section: Introductionmentioning

confidence: 99%

A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films

et al. 2020

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The amalgamation of natural polysaccharides with synthetic polymers often produces fruitful results in the area of drug delivery due to their biodegradable and biocompatible nature. In this study, a series of blend films composed of chitosan (CS)/poly(allylamine hydrochloride) (PAH) in different compositions were prepared as smart drug delivery matrices. The properties of these polymeric films were then explored. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis confirmed an intermolecular hydrogen bonding between CS and PAH. Atomic force microscopy (AFM) revealed improvements in surface morphology as the percentage of PAH in the blend films increased up to 60% (w/w). Water contact angle (WCA) ranged between 97° to 115°, exhibiting the hydrophobic nature of the films. Two films were selected, CTH-1 (90% CS and 10% PAH) and CTH-2 (80% CS and 20% PAH), to test for in vitro cumulative drug release (%) at 37 ± 0.5 °C as a function of time. It was revealed that for simulated gastric fluid (SGF) with pH 1.2, the cumulative drug release (CDR) for CTH-1 and CTH-2 was around 88% and 85% in 50 min, respectively. Both films converted into gel-like material after 30 min. On the other hand, in pH 7.4 phosphate buffer saline (PBS) solution, the maximum CDR for CTH-1 and CTH-2 was 93% in 90 min and 98% in 120 min, respectively. After 120 min, these films became fragments. Sustained drug release was observed in PBS, as compared to SGF, because of the poor stability of the films in the latter. These results demonstrate the excellent potential of blend films in sustained-release drug delivery systems for hydrophilic or unstable drugs.

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“…In some cases, because of the structural and compositional complexity of synthetic polymers, the detailed characterization of a newly developed polymeric material is a challenging task, principally when it is prepared from innovative polymer chemistry, catalysis, or a formulation process. Analytical approaches and methods, for both characterization and degradation features, have a central role in the development of bioresorbable polymer systems and proving the suitability for specific applications . Mass spectrometry (MS) has played an increasingly important role in polymer analysis, thanks also to the improvement in instrumental techniques and the introduction of up‐to‐date configurations.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

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A detailed characterization of polymeric matrices and appropriate degradation monitoring techniques are required to sustain the development of new materials as well as to enlarge the applications of the old ones. In fact, polymer analysis is essential for the clarification of the intrinsic relationship between structure and properties that ascertains the industrial applications in diverse fields. In bioresorbable and biodegradable polymers, the role of analytical methods is dual since it is pointed both at the polymeric matrices and at degradation tracking. The structural architectures, the mechanical and morphological properties, and the degradation rate, are of outstanding importance for a specific application. In some cases, the complexity of the polymer structure, the processes of decomposition or the low concentration of the degradation products need the concurrent use of different complementary analytical techniques to give detailed information of the reactions taking place. Several analytical methods are used in bioresorbable polymer development and degradation tracking. Among them, mass spectrometry (MS) plays an essential role and it is used to refine polymer syntheses, for its high sensitivity, to highlight degradation mechanism by detecting compounds present in trace amounts, or to track the degradation product profile and to study drug release. In fact, elucidation of reaction mechanisms and polymer structure, attesting to the purity and detecting defects as well as residual catalysts, in biodegradable and bioresorbable polymers, requires sensitive analytical characterization methods that are essential in providing an assurance of safety, efficacy and quality. This review aims to provide an overview of the MS strategies used to support research and development of resorbable polymers as well as to investigate their degradation mechanisms. It is focused on the most significant studies concerning synthetic bioresorbable matrices (polylactide, polyglycolide and their copolymers, polyhydroxybutyrate, etc.), published in the last ten years.

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Methods for the Chemical Analysis of Degradable Synthetic Polymeric Biomaterials

Cited by 16 publications

References 111 publications

Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

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