Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

Abstract

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

Collagen–PVA Films Plasticized with Choline Acetate Ionic Liquid for Sustained Drug Release: UV Shielding, Mechanical, Antioxidant, and Antibacterial Properties

“…In this study, the CIP release reached a plateau after 70 min of release . Moreover, Sarwar et al also reported CIP release from sodium alginate/poly(sodium 4-styrenesulfonate) composite films in phosphate buffer, and found that the maximum drug was released in half an hour and attained equilibrium . From all of these findings, it was confirmed that the IL used in the present study may play an important role in prolonged release of CIP from collagen–PVA composite films due to their plasticizing and H-bonding role.…”

Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers

“…E. coli, S. aureus, P. aeruginosa) and Candida species present in DFUs respectively. A number of recent studies have been reported for CIP loaded dressings in the form nanofibers, nanogels, films, scaffolds and wafers for chronic wound application Fan et al, 2021;Fang et al, 2020;Hashemikia et al, 2021;Sarwar et al, 2021). Recent studies have also been reported for FLU loaded dressings in the form of nanofibrous mats, hydrogels and natural rubber latex for fungal infections in wounds (Afrashi et al, 2021;Karthikeyan et al, 2015;Rewak-Soroczynska et al, 2021;Yonashiro Marcelino et al, 2018).…”

Polysaccharide‐based electroconductive films for controlled release of ciprofloxacin

“…58 A number of studies have demonstrated drug carriers for sustained release of CIP via blending of two polymers including Gel, SA, HA, and chitosan in order to eliminate insufficient features such as sensitivity to degradation, poor flexibility and mechanical stability depending on the aimed application field. [59][60][61][62][63][64] Considering all of these, the ternary combination of HA/Gel/SA was prepared in the current study to obtain the drug carrier with improved physico-mechanical characteristics compared to the polymeric network formed by the binary polymer combination or the individual polymer. The drug release results indicated that the CIP release from the HA/Gel/SA-(PEDOT:PSS) polymeric film occurred in a more controlled manner with a slower release rate compared with the previous studies in the literature, since this formulation formed a stronger network, where the drug molecules are encapsulated.…”