Methodological challenges in designing dementia prevention trials — The European Dementia Prevention Initiative (EDPI)

Richard, Edo; Andrieu, Sandrine; Solomon, Alina; Mangialasche, Francesca; Charante, Eric P. Moll van; Coley, Nicola; Fratiglioni, Laura; Neely, Anna Stigsdotter; Vellas, Bruno; Gool, Willem A. van; Kivipelto, Miia

doi:10.1016/j.jns.2012.06.012

Cited by 100 publications

(89 citation statements)

References 69 publications

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“…This result further adds to growing literature that SCD may indeed reflect neuronal changes and suggests that RSN coherence may serve as a good biological predictor of decline [20,21,41]. If FC patterns could be used to identify individuals in a preclinical state of AD, then this technique has the potential to enhance therapeutic or preventative trials to identify disease-modifying treatments that can stop or slow clinical progression [42,43].…”

Section: Discussionmentioning

confidence: 67%

IC‐03‐03: Cognitive Complaints in Older Adults at Risk For Alzheimer’s Disease are Associated with Altered Resting State Networks

Contreras

Goñi

Risacher

et al. 2016

Alzheimer's & Dementia

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Introduction: Pathophysiological changes that accompany early clinical symptoms in prodromal Alzheimer's disease (AD) may have a disruptive influence on brain networks. We investigated resting-state functional magnetic resonance imaging (rsfMRI), combined with brain connectomics, to assess changes in whole-brain functional connectivity (FC) in relation to neurocognitive variables. Methods: Participants included 58 older adults who underwent rsfMRI. Individual FC matrices were computed based on a 278-region parcellation. FastICA decomposition was performed on a matrix combining all subjects' FC. Each FC pattern was then used as a response in a multilinear regression model including neurocognitive variables associated with AD (cognitive complaint index [CCI] scores from self and informant, an episodic memory score, and an executive function score).Results: Three connectivity independent component analysis (connICA) components (RSN, VIS, and FP-DMN FC patterns) associated with neurocognitive variables were identified based on prespecified criteria. RSN-pattern, characterized by increased FC within all resting-state networks, was negatively associated with self CCI. VIS-pattern, characterized by an increase in visual resting-state network, was negatively associated with CCI self or informant scores. FP-DMNpattern, characterized by an increased interaction of frontoparietal and default mode networks (DMN), was positively associated with verbal episodic memory. Discussion: Specific patterns of FC were differently associated with neurocognitive variables thought to change early in the course of AD. An integrative connectomics approach relating cognition to changes in FC may help identify preclinical and early prodromal stages of AD and help elucidate the complex relationship between subjective and objective indices of cognitive decline and differences in brain functional organization.

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Section: Discussionmentioning

confidence: 67%

IC‐03‐03: Cognitive Complaints in Older Adults at Risk For Alzheimer’s Disease are Associated with Altered Resting State Networks

Contreras

Goñi

Risacher

et al. 2016

Alzheimer's & Dementia

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show abstract

“…In 2011, the European Dementia Prevention Initiative (EDPI) [43] met in Stockholm to highlight three new large dementia prevention trials: 1) the Prevention of Dementia by Intensive Vascular Care study (PreDIVA), 2) the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), and 3) the Multidomain Alzheimer Preventive Trial (MAPT) (Table 2). These multi-centered trials emphasize the importance of international collaboration and standardization of study design.…”

Section: Multidomain Interventionsmentioning

confidence: 99%

Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward

Hsu

Marshall

2017

CAR

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The field of Alzheimer disease (AD) prevention has been a culmination of basic science, clinical, and translational research. In the past three years since the new 2011 AD diagnostic guidelines, large-scale collaborative efforts have embarked on new clinical trials with the hope of someday preventing AD. This review will shed light on the historical and scientific contexts in which these trials were based on, as well as discuss potential challenges these trials may face in the coming years. Primary preventive measures, such as lifestyle, multidomain, medication, and supplemental interventions, will be analyzed. Secondary prevention as represented by disease-modifying interventions, such as anti-amyloid therapy and pioglitazone, will also be reviewed. Finally, hypotheses on future directions for AD prevention trials will be proposed.

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“…Непосредственно на уменьшение выраженности когни-тивного дефицита может оказывать влияние снижение повышенного артериального давления [4,48]. В настоя-щее время проводится ряд крупных исследований, в которых оценивается эффект от комплексной модифика-ции сосудистых факторов риска и образа жизни на раз-витие деменции и когнитивных нарушений [5,38].…”

Section: профилактика и лечение постинсультных когнитивных нарушенийunclassified

Poststroke cognitive impairment and dementia

Сергеев¹,

Домашенко²,

Пирадов³

2016

Med. sov.

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В обзоре, подготовленном по данным последних публикаций ведущих европейских специалистов в области постинсультных когнитивных нарушений, приведены краткие сведения о распространенности, механизмах развития и факторах риска этих состояний, которые представляют собой серьезную проблему в период восстановления после инсульта. Описаны общие под-ходы к профилактике постинсультной деменции и возможности нейропротективной терапии у этой категории пациентов. Post-stroke cognitive impairment and dementia are one of the major causes of the disability and quality of life deterioration following cerebrovascular accident. In this review we cover current views on the prevalence, mechanisms and risk factors of post-stroke cognitive deficit, according to recent publications of leading European opinion leaders in this area. We also focus on the approaches to the pharmacological treatment and the role of neuroprotective agents.

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Methodological challenges in designing dementia prevention trials — The European Dementia Prevention Initiative (EDPI)

Cited by 100 publications

References 69 publications

IC‐03‐03: Cognitive Complaints in Older Adults at Risk For Alzheimer’s Disease are Associated with Altered Resting State Networks

IC‐03‐03: Cognitive Complaints in Older Adults at Risk For Alzheimer’s Disease are Associated with Altered Resting State Networks

Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward

Poststroke cognitive impairment and dementia

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