Methodisches zur Fibrinogenbestimmung

Baumann, J.

doi:10.1007/bf02623218

Cited by 15 publications

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“…Bence Jones proteins were also occluded by fibrin, Type K more so than Type L, whereas iodinated thrombin showed no affinity for fibrin.Some effects of clotting conditions on occlusion are also reported, and it is shown that in dilute plasmas occlusion is reduced and in covalently bound fibrin it is enhanced.The retention of proteins present in a clotting medium in the fibrin mesh was defined as 'occlusion' by Morrison (1947) and although its significance for estimating fibrinogen has been recognized by numerous investigators (e.g. Cullen and Van Slyke, 1920;Baumann, 1929;Fearnley, 1951 ;Ratnoff and Menzie, 1951; Laskowski, Rakowitz and Sheraga, 1953) there is very little additional information.Morrison, who first dealt with the problem experimentally, studied the occlusion as the apparent gravimetric yield of fibrin after clotting a fibrinogen solution under standardized conditions with and without the addition of various proteins, viz. albumin, y -globulin, a-and P-lipoproteins or whole serum.…”

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“…The retention of proteins present in a clotting medium in the fibrin mesh was defined as 'occlusion' by Morrison (1947) and although its significance for estimating fibrinogen has been recognized by numerous investigators (e.g. Cullen and Van Slyke, 1920; Baumann, 1929;Fearnley, 1951 ;Ratnoff and Menzie, 1951;Laskowski, Rakowitz and Sheraga, 1953) there is very little additional information.…”

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Occlusion of Plasma Proteins by Human Fibrin: Studies using Trace‐Labelled Proteins

Regoeczi

1968

Br J Haematol

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Summary The occlusion of 13 different proteins by human fibrin has been investigated using radioactive techniques. Each of the proteins examined exhibited different tendencies to be retained by clots. For a satisfactory demonstration of this, studies of the effects of varying protein and fibrinogen concentration were required and are reported here. With normal plasma, the contamination of the syneresed and washed fibrins with albumin and transferrin was negligible whereas significant quantities of β‐lipoproteins, haptoglobin‐haemoglobin complex, free haemoglobin and IgG‐globulins were trapped. Substantial contaminations were noted with macroglobulins (IgA, IgM and α2‐macroglobulin), and above all with plasminogen, of which more than 50 per cent was adsorbed to the fibrin. Bence Jones proteins were also occluded by fibrin, Type K more so than Type L, whereas iodinated thrombin showed no affinity for fibrin. Some effects of clotting conditions on occlusion are also reported, and it is shown that in dilute plasmas occlusion is reduced and in covalently bound fibrin it is enhanced.

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confidence: 99%