Method validation using weighted linear regression models for quantification of UV filters in water samples

Silva, Claudia Pereira da; Emídio, Elissandro Soares; Marchi, Mary Rosa Rodrigues de

doi:10.1016/j.talanta.2014.07.041

Cited by 38 publications

(36 citation statements)

References 25 publications

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“…The residues were plotted against the concentrations of the analytical curves. 29,30 R = S exp − S int (2) With a well-adjusted model, one can do the analysis of variance to test the statistical significance of the linear regression equation. A good way to evaluate this is by comparing the mean of the quadratic sum variance explained in the model ( ) by the average quadratic sum of the residue ( ).…”

Section: Linearitymentioning

confidence: 99%

Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti-Alzheimer Drug Galantamine and other Amaryllidaceae Alkaloids in Plants

Paiva

Souza

Pereira

et al. 2020

J. Braz. Chem. Soc.

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Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine in Amaryllidaceae species (Hippeastrum elegans, Habranthus cf. irwinianus, Hymenocallis littoralis and Griffinia nocturna). The alkaloids were extracted from dried and ground bulbs (100 mg) using liquid-liquid microextraction followed by solid phase extraction in cation exchange cartridges. The quantification method showed good linearity (correlation coefficient, R ≥ 0.9968) and selectivity for a run time of 10 min. All values were within the acceptable limits for recovery (87.5-96.2%), interday (coefficient of variation, CV%, 1.3-8.4%) and intraday precision (CV% 5.7-8.1%), except narciclasine (70%). The limits of detection and quantification were 5-100 and 20-350 ng mL-1 , respectively. Our method demonstrated to be rapid, sensitive and reliable, therefore appropriate for being employed in the prospection of new source of galantamine and other alkaloids.

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Section: Linearitymentioning

confidence: 99%

Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti-Alzheimer Drug Galantamine and other Amaryllidaceae Alkaloids in Plants

Paiva

Souza

Pereira

et al. 2020

J. Braz. Chem. Soc.

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“…The high sample volumes in this procedure, usually from 100 mL (Goksoyr et al, 2009;Liu et al, 2010) up to 1.0 L (Kameda et al, 2011;Liu et al, 2011) is the main disadvantage of this technique. Because UV-filters are relatively polar, the great majority of authors use intermediate polarity solvents like dichloromethane (DCM) (Goksoyr et al, 2009;Kameda et al, 2011;Lambropoulou et al, 2002;Tashiro and Kameda, 2013) or ethyl acetate (EA) (Arukwe et al, 2012;Balmer et al, 2005;da Silva et al, 2015;Negreira et al, 2008;Poiger et al, 2004) to extract water samples. However, Rodil et al (2012) used a more polar solvent, methanol (MeOH), which is justified by the complex mixture analysed, containing not only very polar UV-filters (like PBSA and BP4), but also other polar compounds like pharmaceuticals and herbicides.…”

Section: Extraction Techniques For Water Analysismentioning

confidence: 99%

Advances in analytical methods and occurrence of organic UV-filters in the environment — A review

Ramos

Homem

Alves

et al. 2015

Science of The Total Environment

263

110

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UV-filters are a group of compounds designed mainly to protect skin against UVA and UVB radiation, but they are also included in plastics, furniture, etc., to protect products from light damage. Their massive use in sunscreens for skin protection has been increasing due to the awareness of the chronic and acute effects of UV radiation. Some organic UV-filters have raised significant concerns in the past few years for their continuous usage, persistent input and potential threat to ecological environment and human health. UV-filters end up is wastewater and because wastewater treatment plants are not efficient in removing them, lipophilic compounds tend to sorb onto sludge and hydrophilics end up in river water, contaminating the existing biota. To better understand the risk associated with UV-filters in the environment a thorough review regarding their physicochemical properties, toxicity and environmental degradation, analytical methods and their occurrence was conducted.Higher UV-filter concentrations were found in rivers, reaching 0.3 mg/L for the most studied family, the benzophenone derivatives. Concentrations in the ng to µg/L range were also detected for the paminobenzoic acid, cinnamate, crylene and benzoyl methane derivatives in lake and sea water.Although at lower levels (few ng/L), UV-filters were also found in tap and groundwater. Swimming pool water is also a sink for UV-filters and its chlorine by-products, at the µg/L range, highlighting the benzophenone and benzimidazole derivatives. Soils and sediments are not frequently studied, but concentrations in the µg/L range have already been found especially for the benzophenone and crylene derivatives. Aquatic biota is frequently studied and UV-filters are found in the ng/g-dw range with higher values for fish and mussels. It has been concluded that more information regarding UVfilter degradation studies both in water and sediments is necessary and environmental occurrences should be monitored more frequently and deeply. SEHSDT -sequential extraction with high-speed dispersion tool; SLE -solid-liquid extraction; SPEsolid-phase extraction; SPF -sun protection factor; SPLE -selective pressurized liquid extraction;SPMDs -semipermeable membrane devices; SPME -solid phase microextraction; TD -thermal desorption; TCE -tetrachloroethylene; THF -tetrahydrofuran; Tl -toluene; UPLC -ultraperformance liquid chromatography; USE -ultrasound extraction; UV -ultraviolet; WTP -water treatment plant; WWTP -wastewater treatment plant 4

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“…Lipid species with levels below their respective LOD were considered absent and those with levels below LOQ were not quantified and hence not used for calculation of total amounts of lipid within the assessed lipid classes. A weighted calibration curve (1/Y) was used for TG and FAs, due to significant heteroscedasticity of the data 38 .…”

mentioning

confidence: 99%

Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes

Gil-Ramírez

Rosmark

Sartipy

et al. 2020

Sci Rep

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Vascular bio-scaffolds produced from decellularized tissue offer a promising material for treatment of several types of cardiovascular diseases. these materials have the potential to maintain the functional properties of the extracellular matrix (ecM), and allow for growth and remodeling in vivo. the most commonly used methods for decellularization are based on chemicals and enzymes combinations, which often damage the ECM and cause cytotoxic effects in vivo. Mild methods involving pressurized co 2 -ethanol (EtOH)-based fluids, in a supercritical or near supercritical state, have been studied for decellularization of cardiovascular tissue, but results are controversial. Moreover, data are lacking on the amount and type of lipids remaining in the tissue. Here we show that pressurized co 2 -etoH-H 2 O fluids (average molar composition, Χ CO2 0.91) yielded close to complete removal of lipids from porcine pulmonary arteries, including a notably decrease of pro-inflammatory fatty acids. Pressurized co 2 -limonene fluids (Χ CO2 0.88) and neat supercritical CO 2 (scco 2 ) achieved the removal of 90% of triacylglycerides. Moreover, treatment of tissue with pressurized co 2 -limonene followed by enzyme treatment, resulted in efficient DNA removal. The structure of elastic fibers was preserved after pressurized treatment, regardless solvent composition. in conclusion, pressurized co 2 -ethanol fluids offer an efficient tool for delipidation in bio-scaffold production, while pressurized CO 2 -limonene fluids facilitate subsequent enzymatic removal of DNA.Cardiovascular diseases (CVDs) are responsible for 17.9 million deaths per year in the world (31% of total deaths) 1 . In 2015, the global prevalence of arterial hypertension (AHT), the most prevalent risk factor for CVD development, was estimated to be around 30-45% of the adult population, increasing up to 60% in people above 60 years of age 2 . Moreover, the prevalence of AHT is estimated to increase by 15-20% in 2025 2 . Pulmonary arterial hypertension (PAH), a sub-form of AHT, is characterized by breakdown of elastic fibers and alterations in the cross-linking of collagen, resulting in remodeling the extracellular matrix (ECM) in pulmonary arteries 3,4 . Hypertrophic remodeling of the media and endothelial cell dysfunction result in a high vascular resistance and thrombosis 4,5 , potentially leading to right ventricular failure and death in severely affected patients.Organ or tissue transplantation is the last option proposed for such CVDs-affected patients with a poor prognosis. However, the lack of compatible organs and tissues constitutes a major limitation. Even though the global rate of transplantation increased by 7.25% between 2015 and 2016, reaching a rate of 15.5 organs transplanted per hour 6 , less than 10% of the transplant needs are covered. Consequently, patients often have to wait long time for transplantation, resulting in worsening of their medical condition. Furthermore, those that are offered a transplantation require life-long immune therapy to redu...

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Method validation using weighted linear regression models for quantification of UV filters in water samples

Cited by 38 publications

References 25 publications

Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti-Alzheimer Drug Galantamine and other Amaryllidaceae Alkaloids in Plants

Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti-Alzheimer Drug Galantamine and other Amaryllidaceae Alkaloids in Plants

Advances in analytical methods and occurrence of organic UV-filters in the environment — A review

Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes

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