Method of heart transplantation for treatment of hypoplastic left heart syndrome

Preoperative management for tricuspid regurgitation in hypoplastic left heart syndrome

“…Due to the generally unsatisfactory results of surgery using the Norwood procedure, heart transplantations for HLHS patients are now being performed in some institutions, and heart transplantation has become established as one treatment option in Western countries and good results have been obtained. 11 But because the lack of donor hearts for heart transplantation remains a major problem, the Norwood procedure is an important bridging operation for patients waiting for heart transplantation. Because heart transplantation for infants with HLHS is not currently an option in Japan, improvement in the HLHS surgery is of great importance.…”

Cardiac transplantation for hypoplastic left heart syndrome

“…5 Suitable infants listed for transplantation are palliated with prostaglandin E-1 to maintain ductal patency while awaiting a suitable donor. 6 Subsequently, the arterial duct can be stented, and the branches of the pulmonary trunk banded, either surgically 7 or interventionally to provide stabilization of the pulmonary and systemic blood flows prior to transplantation. The competing outcomes after listing an infant with hypoplastic left heart syndrome are transplantation, death, or surgical palliation.…”

“…While waiting time is dangerous, and providers of care are tempted to reconsider surgical options, the outcomes of crossover from listing to transplant is poor. 5,6 In the data collected by the Pediatric Heart Transplant Society, the mean time to first surgical palliation after listing was 30.13 days, the age at first palliation was 43.08 days, and the mortality was 52%. In contrast, mortality of primary Norwood palliation in infants with hypoplastic left heart syndrome is significantly lower, approximately 33%.…”

A European perspective on the management of hypoplastic left heart syndrome

“…Anyone working in the management of congenital cardiac malformations in the current era is aware of the pioneering role the United States of America have played in the evolution of the treatment of hypoplastic left heart syndrome. The energy, scientific curiosity, commitment, resources, and sheer belief in the value of life drove Norwood, 2-7 Bove [8][9][10][11] and Spray 12 sequentially to evolve the three stage procedures we have come to know as the Norwood sequence, and Bailey [13][14][15][16][17][18][19][20][21] to work out the bases of cardiac transplantation in children. Whilst there was work on hypoplastic left heart syndrome being done in Europe during this era, it was both small in quantity, and limited in impact.…”