Preoperative management for tricuspid regurgitation in hypoplastic left heart syndrome

Baba, Kenji; Ohtsuki, Shin Ichi; Kamada, Masahiro; Kataoka, Koichi; Ohno, Naoki; Okamoto, Yoshio; Takeuchi, Mamoru; Iwasaki, Tadaaki; Sano, Shunji; Morishima, Tsuneo

doi:10.1111/j.1442-200x.2008.02731.x

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…4) displayed a similar prognosis to HLHS peers without TVR (p = 0.59 and p = 0.88, respectively). Our results may imply that TV repair, together with the improved pre-and post-operative medical management [42,43], can restore the original prognosis of HLHS patients with TVR, counteracting the deleterious effect that untreated TVR has on the patient's survival.…”

Section: Discussionmentioning

confidence: 77%

Tricuspid valve repair can restore the prognosis of patients with hypoplastic left heart syndrome and tricuspid valve regurgitation: a meta-analysis

Ponzoni

Azzolina

Vedovelli

et al. 2023

Preprint

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Objectives To date, evidence supporting the efficacy of tricuspid valve (TV) repair in interrupting the progression of systemic right ventricular (RV) adverse remodeling in hypoplastic left heart syndrome (HLHS) is conflicting. We performed a systematic review and meta-analysis of scientific literature to assess the impact of TV repair in effectively modifying the prognosis of patients with HLHS. Methods We conducted a systematic review of PubMed, Web of Science, and Scopus databases. A random-effect meta-analysis was performed and transplant-free survival, freedom from TV regurgitation, and TV reoperation data were reconstructed using the published Kaplan–Meier curves. Results Nine studies were included, for a total of 203 HLHS patients undergoing TV repair and 323 HLHS controls. The estimated transplant-free survival at 1, 5, and 10 years of follow-up was 75.5% [95% confidence interval (CI) = 67.6–84.3%], 63.6% [95% CI = 54.6–73.9%], and 61.9% [95% CI = 52.7–72.6%], respectively. Transplant-free survival was comparable to HLHS peers without TV regurgitation (p = 0.59). Five-year freedom from recurrence of TV regurgitation and freedom from TV reoperation was 57% [95% CI = 46.7–69.7%] and 63.6% [95% CI = 54.5–74.3%], respectively. Younger age and TV repair at the time of Norwood operation increased the risk of TV regurgitation recurrence and the need for TV reoperation. Conclusions Our meta-analysis supports the efficacy of TV repair in modifying favorably the prognosis of patients with HLHS and TV regurgitation, reestablishing a medium-term transplant-free survival which is comparable to HLHS peers. However, durability of surgery and long-term fate of TV and RV performance are still unclear.

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Section: Discussionmentioning

confidence: 77%

Tricuspid valve repair can restore the prognosis of patients with hypoplastic left heart syndrome and tricuspid valve regurgitation: a meta-analysis

Ponzoni

Azzolina

Vedovelli

et al. 2023

Preprint

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“…The prognosis of infants with HLHS has markedly improved recently due to developments in perioperative management and in surgical methods . It remains significantly poorer, however, in infants with HLHS with an intact/restrictive atrial septum and hypoxemia, acidosis, pulmonary congestion, high PVR, or other issues presenting soon after birth.…”

Section: Discussionmentioning

confidence: 99%

Balloon atrial septostomy in hypoplastic left heart syndrome with restrictive atrial septum

Fukushima

Baba²,

Kondo³

et al. 2019

Pediatrics International

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Background: Rashkind balloon atrial septostomy (BAS) can be challenging in infants with hypoplastic left heart syndrome (HLHS) and small atrial septal defect (ASD). Methods: We retrospectively reviewed all infants with HLHS who underwent surgery and BAS between January 2006 and December 2015. The infants were divided into three groups: no BAS; catheter BAS; and open AS. Infants who underwent catheter BAS were divided into two groups based on atrial septal anatomy: standard and complex. Results: Of the 70 patients, 57 (81%) underwent Glenn surgery. Subsequently, a significant difference in survival was observed: 86% (44/51), 91% (10/11), and 25% (2/8) in the no BAS, catheter BAS, and open AS groups, respectively (P = 0.0002). No significant difference was seen between the no BAS and the catheter BAS groups (P = 1.0). In the 56 patients who underwent catheterization after surgery, no intergroup differences in mean pulmonary artery pressure, pulmonary vascular resistance, or pulmonary artery index were found. We classified catheter BAS into standard (n = 5) and complex (n = 5) based on ASD location, and septum thickness. All patients in the standard group underwent complete Rashkind BAS, but in the complex group, only one patient underwent complete Rashkind BAS, with the remaining requiring initial static BAS (P = 0.048). Following septostomy, ASD size, ASD flow, and percutaneous oxygen saturation (SpO 2 ) were not significantly different between the two groups. Conclusions: Catheter BAS is effective in infants with HLHS and a restrictive atrial septum. Infants with standard or complex atrial septum can achieve equivalent outcomes despite more patients often requiring static BAS.

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“…Sometimes even a temporary discontinuation of the prostaglandin infusion is possible, with careful monitoring of blood pressure and urine volume as well as frequent echocardiographic examinations, in order to enable maintenance of balance between systemic and pulmonary blood flow. (4) Balance the circulation The p / s ratio preoperatively is dictated by the adequacy of the interatrial communication. An infant with a mildly restrictive interatrial communication may have balanced circulation and remain in a clinically stable condition as long as the ductus arteriosus remains open.…”

Section: Open the Ductusmentioning

confidence: 99%

Preoperative management of hypoplastic left heart syndrome

2009

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Preoperative management for tricuspid regurgitation in hypoplastic left heart syndrome

Cited by 6 publications

References 16 publications

Tricuspid valve repair can restore the prognosis of patients with hypoplastic left heart syndrome and tricuspid valve regurgitation: a meta-analysis

Tricuspid valve repair can restore the prognosis of patients with hypoplastic left heart syndrome and tricuspid valve regurgitation: a meta-analysis

Balloon atrial septostomy in hypoplastic left heart syndrome with restrictive atrial septum

Preoperative management of hypoplastic left heart syndrome

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