Method of determination of the kinetic isotope effect in a mixture of reacting isotopomers

Mitchenko, R. S.; Krasnyakova, T. V.; Zhikharev, I. V.; Митченко, С. А.

doi:10.1007/s11237-012-9255-9

Cited by 5 publications

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“…The effect of candesartan on the state of vasoactive NO pool and activity of the antioxidant system is complemented by the action of lacidipine, a calcium channel blocker (CCB) of the third generation. It has been demonstrated previously that CCB can affect the endothelial function not only through a decrease in the Ca 2+ concentration, but also through an increase in the NO production, which is a powerful vascular relaxing factor [19]. It was found that CCB are able to: 1) release the deposited NO [20]; 2) specifically enhance the expression of e-NOS; 3) enhance the stimulation effect of NO on the cyclic guanosine monophosphate (cGMP) expression which lowers the intracellular calcium concentration in the smooth muscles, leading to their relaxation and vasodilation; 4) store NO from its binding with O 2to form peroxynitrite.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

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Gerasimchuk

Kovalyova

et al. 2018

Romanian Journal of Internal Medicine

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Introduction. Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. This process is proven to have contributed by immune inflammation activation which is mediated by pro-inflammatory cytokines and oxidative stress. Aims. To investigate the additional benefits of the combined antihypertensive therapy with lacidipine and candesartan on the basis of studying their antioxidant properties, impact on endothelial function and pro-inflammatory cytokines activity in hypertensive patients with overweight and obesity. Methods. A combination of a calcium channel blocker and angiotensin receptor blocker (lacidipine 2 mg, 4 mg, and candesartan 4mg, 8mg, 16mg) was prescribed to 30 patients with essential hypertension of grades 1-3, 30 to 65 years old (mean age - 54.7 ± 5.8 years), who previously have not been receiving regular antihypertensive therapy. Results. During the course of combined antihypertensive therapy with lacidipine and candesartan, a significant reduction in i-NOS activity, TNF-α to its type I soluble receptor ratio (TNF- α/sTNF-αRI), and oxidative stress marker - 8-iso-PgF2α has been observed. Activity of e-NOS, levels of SOD and catalase, in contrast, have increased by the end of observation period. Conclusion. The improvement of endothelial function due to lower level of oxidative stress and a significant decrease of immune activation has been observed in hypertensive patients with overweight and obesity under the influence of combined antihypertensive therapy with lacidipine and candesartan.

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Section: Discussionmentioning

confidence: 99%

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

Ащеулова

Gerasimchuk

Kovalyova

et al. 2018

Romanian Journal of Internal Medicine

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MCl₂ (M=Hg, Cd, Zn, Mn) catalysed hydrochlorination of acetylene – a Density Functional Theory study

et al. 2016

Molecular Simulation

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New stereoselective $$C_{sp^2 } - C_{sp^3 }$$ coupling: Catalytic iodomethylation of acetylene with methyl iodide into E-1-iodopropene

2014

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Method of determination of the kinetic isotope effect in a mixture of reacting isotopomers

Cited by 5 publications

References 3 publications

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

MCl₂ (M=Hg, Cd, Zn, Mn) catalysed hydrochlorination of acetylene – a Density Functional Theory study

New stereoselective $$C_{sp^2 } - C_{sp^3 }$$ coupling: Catalytic iodomethylation of acetylene with methyl iodide into E-1-iodopropene

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Method of determination of the kinetic isotope effect in a mixture of reacting isotopomers

Cited by 5 publications

References 3 publications

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients

MCl2 (M=Hg, Cd, Zn, Mn) catalysed hydrochlorination of acetylene – a Density Functional Theory study

New stereoselective $$C_{sp^2 } - C_{sp^3 }$$ coupling: Catalytic iodomethylation of acetylene with methyl iodide into E-1-iodopropene

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MCl₂ (M=Hg, Cd, Zn, Mn) catalysed hydrochlorination of acetylene – a Density Functional Theory study