Method for the determination of the total fluorine content of whole blood, serum/plasma, and other biological samples

Belisle, Jon; Hagen, D.F.

doi:10.1016/0003-2697(78)90704-2

Cited by 44 publications

(10 citation statements)

References 19 publications

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“…Many methods have been reported for the determination of fl uoride in blood and/or urine using a colorimetric method [16], an ion-selective electrode [17,18], ion chromatography [19], gas chromatography (GC) [15,20], and capillary electrophoresis [21,22]. However, because the majority of these methods detect fl uoride only on the basis of its absorbance and/or retention time, they sometimes lack specifi city.…”

Section: Introductionmentioning

confidence: 99%

Determination of fluoride in human whole blood and urine by gas chromatography-mass spectrometry

Kage¹,

Kudo

Nishida

et al. 2008

Forensic Toxicol

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Section: Introductionmentioning

confidence: 99%

Determination of fluoride in human whole blood and urine by gas chromatography-mass spectrometry

Kage¹,

Kudo

Nishida

et al. 2008

Forensic Toxicol

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“…In this way the limit of detection (LOD) of ≈0.01 mg/l was achieved. 149 Various chromatographic methods for fluoride determination include ion chromatography (IC), 150 gas chromatography (GC) 151,152 and high-performance liquid chromatography (HPLC). 153 The main issues related to the use of IC are that fluoride peak tends to overlap with the water negative dip and that monocarboxylic acids interfere because of co-elution with fluoride or only partial resolution.…”

Section: Methods For Determination Of Fluoridementioning

confidence: 99%

Fluoride in Human Health and Nutrition

Štepec

Ponikvar‐Svet

2019

ACSi

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Fluorine is in the form of fluorides ubiquitous in nature and as such an inevitable part of our environment. In small amounts, it is known to have beneficial effects on dental health. On the other hand, excessive chronic intakes can result in adverse effects including the development of dental fluorosis in children and/or skeletal fluorosis in both children and adults. The adequate intake has been set, based on empirical observations, at 0.05 mg/day/kg body weight however, the threshold between beneficial and harmful effects is narrow. Despite numerous studies, knowledge on the fluoride toxicity is still relatively poor. In this review, the role and the effects of fluoride on human health are enlightened. Some of the fluoride controversies are discussed and future research directions suggested.

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“…12,13 The total content of fluorine in whole blood, serum/plasma and other biological samples was determined by GC using oxygen bomb combustion and reaction with triethylsilanol. 14 In the GC determination of fluorinated organic compounds after suitable derivatization the electron capture detection (ECD) can be used, 15,16 but as it was recently showed in the determination of perfluorinated carboxylic acids (PFCA) C6 to C12 after the derivatization with isobutyl chloroformate, evidently better values of the LOD can be obtained for the mass spectrometry (MS) detection with electron impact ionization, than the ECD. 16 The GC measurements with various derivatization procedures is in fact the most frequently applied for this purpose.…”

Section: Introductionmentioning

confidence: 99%

“…21 Recently in our research group we have developed a HPLC method as mentioned above for the determination of TOF, based on the transformation of fluoride into TPSiF. 10 As this compound is volatile, although the separation requires a higher temperature than the earlier used trialkylfluorosilanes, 12,14 it can be also determined by the GC with various detection methods. The aim of this work was to develop a GC method for the determination of TOF with the use of the earlier developed defluorination procedure with SBP and derivatization of fluoride to TPSiF.…”

Section: Introductionmentioning

confidence: 99%

Application of Gas Chromatography to Determination of Total Organic Fluorine after Defluorination of Perfluorooctanoic Acid as a Model Compound

Koc¹,

Donten²,

Musijowski³

et al. 2011

Croat. Chem. Acta

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Abstract. Because of the global presence of anthropogenic perfluorinated organic compounds in the environment, foods and living organisms, and their large structural variety, it can be helpful to develop a method for determination of their total content at trace level in different matrices. In the developed method, the defluorination was carried with sodium biphenyl, derivatization of released fluoride to triphenylfluorosilane and determination by gas chromatography. Three detection methods were compared: flameionization detection, electron capture detection and mass spectrometry. Among them the MS detection was found to be the most favorable one in terms of the instrumental limit of detection (LOD) , whereas the flame-ionization detection was considered to be the most favorable in terms of the method limit of detection (MDL). For the initial sample volume of 1 L and performing the whole procedure of determination, including preconcentration, the MDL value for perfluorooctanoic acid was evaluated as 0.043 ppb.

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Method for the determination of the total fluorine content of whole blood, serum/plasma, and other biological samples

Cited by 44 publications

References 19 publications

Determination of fluoride in human whole blood and urine by gas chromatography-mass spectrometry

Determination of fluoride in human whole blood and urine by gas chromatography-mass spectrometry

Fluoride in Human Health and Nutrition

Application of Gas Chromatography to Determination of Total Organic Fluorine after Defluorination of Perfluorooctanoic Acid as a Model Compound

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