Method for enhancing bioavailability of myricetin based on self‐assembly of casein–myricetin nanomicelles

Abstract

In order to expand the application in the medical field and enhance pharmacological effects, casein-myricetin nanomicelles were prepared by the self-assembly method and characterised by ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy. The parameters in self-assembly were optimised according to the factors of particle size, encapsulation yield, and drug loading. The result showed a pH of 5.5, a casein concentration of 2 mg/ml, a mass ratio of casein to myricetin of 8:1, ultrasonic power of 300 W, ultrasonic time of 5 min and ethanol volume of 7 ml were the optimal conditions. The situ cycle intestinal perfusion methods indicated that casein-myricetin nanomicelles can be more easily absorbed by small intestine than myricetin standard sample. Therefore, casein micelles are effective for improving the water solubility of myricetin.

Characterization of starch biofilm reinforced with cellulose microfibers isolated from Musa Saba' midrib residue and its application as an active packaging film

“…This analysis was conducted in accordance with the Regulation (EU) 10/2011, which outlines the safety requirements for plastic materials that come into contact with food as addressed in the European Framework Regulation (EU) 1935/2004 45 . Myricetin has a characteristic absorption peak of flavonoids at 254 nm, 69 which was used to monitor its release behavior using a UV–visible spectrophotometer. The release profile of myricetin increased over time, as indicated by the increase in the absorbance values for three different profiles in Figure 8a.…”

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

“…Macromolecular proteins have better biocompatibility, biodegradability, and biosafety, and thus Guo and colleagues combined Myr with macromolecular proteins to improve its physical and chemical properties, while retaining its efficacy. 76 The dietary protein casein also has good biodegradability and biocompatibility when taken orally, and in addition is an amphiphilic protein with good self-assembly characteristics. The hydrophobic sites of these proteins can be self-assembled with Myr through hydrophobic interactions, and the preparation process is simple.…”

Natural Biocidal Compounds of Plant Origin as Biodegradable Materials Modifiers

“…Chitosan, chitosan-based, and starch materials could be applied as myricetin carriers used in the therapy of various diseases [ 201 – 203 ]. Certain biopolymers improve the bioavailability of myricetin [ 204 ]. Chitosan loaded with flavonols (myricetin, kaempferol, and quercetin) is considered to be an excellent active packaging material due to its modified properties (antimicrobial, antioxidant, etc.)…”