Method 8290: an analytical protocol for the multimedia characterization of polychlorinated dibenzodioxins and dibenzofurans by high-resolution gas chromatography/high-resolution mass spectrometry

Tondeur, Yves; Beckert, Werner F.; Billets, Stephen; Mitchum, R. K.

doi:10.1016/0045-6535(89)90112-4

Cited by 24 publications

(21 citation statements)

References 4 publications

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“…Nominal detection limits for dioxins and furans were 0.1 ng/g wet weight for eggs except for octaCDD and octaCDF that were 0.3 and 0.2 ng/g; tetraCDD and tetraCDF averaged 0.02 ng/g. The procedure used matrix-specific extraction, analyte-specific cleanup, and high-resolution gas chromatography/high resolution mass spectrometry analysis techniques by a method of internal standard quantitation polychlorinated dibenzo[ p]dioxin using [ 13 C 12 ] polychlorinated dibenzo[ p]dioxin surrogates (Tondeur, 1990;U.S. Environmental Protection Agency, 1990).…”

Section: Chemistrymentioning

confidence: 99%

Contaminant Exposure of Barn Swallows Nesting on Bayou D'Inde, Calcasieu Estuary, Louisiana, USA

Custer

Goatcher

et al. 2006

Environ Monit Assess

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Current and historical point source discharges, storm water runoff, and accidental spills have contaminated the water, sediment, and biota within the Calcasieu Estuary in southwestern Louisiana. In 2003, barn swallow (Hirundo rustica) eggs and nestlings were collected beneath two bridges that cross Bayou d'Inde, the most contaminated waterway within the Calcasieu Estuary. Samples were also collected from a bridge over Bayou Teche, a reference site in south central Louisiana. Polychlorinated biphenyl (PCB) concentrations in barn swallow eggs and nestlings were significantly higher at the downstream site on Bayou d'Inde (2.8 micro g/g PCBs in eggs and 1.5 micro g/g PCBs in nestlings) than at the other two sites (< 0.2 micro g/g PCBs in eggs and nestlings at both sites). Ethoxyresorufin-O-dealkylase activity in nestling livers was significantly higher at the downstream site on Bayou d'Inde (50 pmol/min/mg) compared to the other two locations (24 pmol/min/mg, each), probably because of exposure to PCBs. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran concentrations in eggs and polycyclic aromatic hydrocarbons in nestlings were at background concentrations at all sites. Trace element concentrations in barn swallow eggs and nestling livers were at background levels and did not differ among the three sites. A biomarker of DNA damage did not differ among sites.

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Section: Chemistrymentioning

confidence: 99%

Contaminant Exposure of Barn Swallows Nesting on Bayou D'Inde, Calcasieu Estuary, Louisiana, USA

Custer

Goatcher

et al. 2006

Environ Monit Assess

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“…Moreover, Supplemental Figs. 5 and 6 demonstrate the absence of analytical detector and sample handling artifacts, and/or chemical interferences susceptible of distorting the congener profiles (Tondeur et al, 1984;Tondeur, 1987). Fig.…”

Section: Resultsmentioning

confidence: 96%

Significance of measuring non-2,3,7,8-substituted PCDD/PCDF congeners and the identification of a new mechanism of formation for a high-temperature industrial process

Tondeur¹,

Vining²,

Serne

et al. 2015

Chemosphere

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“…We analyzed tissue samples of dosed LE rats (results will be published elsewhere), which were injected on GC/HRMS in a timely manner after the sample preparation, and the recoveries of 13 A serum sample and a solid tissue sample consumed about 63 mL and 131 mL of organic solvents in the sample preparation, respectively. This was only 1/5 of consumption comparing to the conventional methods (6,9). Furthermore, each sample only used 3.2 mL of methylene chloride, a hazardous chlorinated solvent.…”

Section: Resultsmentioning

confidence: 99%

A Screening Method for Polychlorinated Dibenzo-p-dioxins (PCDDs), Dibenzofurans (PCDFs), and Non-Ortho Polychlorinated Biphenyls (PCBs) in Biological Matrixes

Chen

Hass

Albro

2000

Environ. Sci. Technol.

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We have developed a screening method for analyzing tetra-and penta-chlorinated dibenzo-p-dioxins/dibenzofurans (CDD/F), octa-CDF, and non-ortho polychlorinated biphenyls (PCBs) in biological matrixes to reduce the cost and time of dioxin analysis. Spiked control Long Evans (LE) rat liver, adipose tissue, serum, placenta, and whole fetus were analyzed to validate the method and to determine the method detection limit (MDL). Mixed with formic acid, serum samples were extracted with n-heptane. Solid tissues were ground to powder with anhydrous sodium sulfate and were sonicated with acetonitrile; the supernate was passed through a C-18 cartridge, and analytes were eluted with n-heptane. A dual-column unit composed of 40% H 2 SO 4 -coated silicic acid and activated acidic alumina was used for further cleanup. The extracts after cleanup were analyzed by high-resolution gas chromatography (HRGC)/ high-resolution mass spectrometry (HRMS) using an isotope dilution technique. The method needed half the time and one-fifth the amount of organic solvents for sample preparation, compared to traditional liquid/liquid or Soxhlet extraction. The method also saved two-thirds of the time on GC/MS analysis. Sub-pg/g level of sensitivity was achieved using gram-sample quantities.

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Method 8290: an analytical protocol for the multimedia characterization of polychlorinated dibenzodioxins and dibenzofurans by high-resolution gas chromatography/high-resolution mass spectrometry

Cited by 24 publications

References 4 publications

Contaminant Exposure of Barn Swallows Nesting on Bayou D'Inde, Calcasieu Estuary, Louisiana, USA

Contaminant Exposure of Barn Swallows Nesting on Bayou D'Inde, Calcasieu Estuary, Louisiana, USA

Significance of measuring non-2,3,7,8-substituted PCDD/PCDF congeners and the identification of a new mechanism of formation for a high-temperature industrial process

A Screening Method for Polychlorinated Dibenzo-p-dioxins (PCDDs), Dibenzofurans (PCDFs), and Non-Ortho Polychlorinated Biphenyls (PCBs) in Biological Matrixes

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