Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats

Özden, Sibel; Karademir, Betül; Gezginci‐Oktayoglu, Selda; Arda-Pirincci, Pelin; Bolkent, Şehnaz; Alpertunga, Büket

doi:10.1016/j.fct.2009.04.018

Cited by 52 publications

(23 citation statements)

References 73 publications

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“…Glutathione dependent defense against xenobiotic toxicity is a multifaceted phenomenon that has been well characterized in animals. GSH plays a key role in the detoxification of the reactive toxic metabolites and liver necrosis is known to be initiated when reserves of GSH are depleted (Ozden et al, 2009). In the present study, the decrease of renal GSH level (73.52%) was more than the decrease of hepatic GSH level (37.43%) confirming that liver has more antioxidant potential than kidney.…”

Section: Antioxidant Enzymessupporting

confidence: 63%

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Al‐Othman¹

2011

Afr. J. Pharm. Pharmacol.

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Protection from effects of the organophosphate insecticide, malathion on the liver and kidney of male Wistar albino rats by -tocopherol and selenium was investigated. Significantly greater (P<0.01) mean concentrations of malondialdehyde (MDA) and lesser concentrations (P<0.01) of reduced glutathione (GSH) and tissues total proteins were observed in liver and kidney of rats exposed to malathion. Activities of the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were less in livers and kidneys of rats exposed to malathion. These effects caused by exposure to malathion were reversed when rats were subsequently treated orally with 100 mg/kg b.w. tocopherol and/or 0.1 mg selenium/kg b.w. Both tocopherol and selenium (Se) reduced the concentration of MDA, and increased concentration of total proteins and reduced glutathione and mean activities of SOD, CAT and GPx, to levels that were not significantly different from unexposed, control rats, previous to exposure to malathion. Selenium was significantly (P<0.05) more effective at recovering activities of SOD and GPx in liver and kidney of malathion treated rats than wastocopherol, whereas, -tocopherol was significantly (P<0.05) more effective at recovering activities of CAT in liver and kidney than was Se. Both -tocopherol and Se were effective in alleviating oxidative damage in liver and kidney of rats caused by malathion.

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Section: Antioxidant Enzymessupporting

confidence: 63%

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Al‐Othman¹

2011

Afr. J. Pharm. Pharmacol.

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“…Pesticides are widely used by human beings, although their toxicity (Ozden et al 2009;Ferrer 2003) and their impact on the environment have caused concern about their uses. Synthetic pesticides have also generated resistance in houseflies (Scott et al 2000;Acevedo et al 2009) and consequently need to be replaced by new compounds.…”

Section: Resultsmentioning

confidence: 99%

Insecticidal activity of essential oils from native medicinal plants of Central Argentina against the house fly, Musca domestica (L.)

et al. 2009

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The insecticidal activity of nine essential oils (EOs) against the house fly (Musca domestica) was evaluated by placing flies in a screw-cap glass jar holding a piece of EO-treated cotton yarn. The dose necessary to kill 50% of flies (LC(50)) in 30 min was determined at 26 +/- 1 degrees C. The EOs showed LC(50) values ranging from 0.5 to 46.9 mg/dm(3). The EO from Minthostachys verticillata was the most potent insecticide (LC(50) = 0.5 mg/dm(3)) followed by EOs from Hedeoma multiflora (LC(50) = 1.3 mg/dm(3)) and Artemisia annua (LC(50) = 6.5 mg/dm(3)). The compositions of the nine EOs, obtained by hydrodistillation of medicinal herbs, were analyzed by gas chromatography/mass spectroscopy. These analyses showed that (4R)(+)-pulegone (69.70%), menthone (12.17%), and limonene (2.75%) were the principal components of M. verticillata EO. (4R)(+)-pulegone was also the main constituent (52.80%) of H. multiflora, while artemisia ketone (22.36%) and 1,8-cineole (16.67%) were the major constituents of A. annua EO. The terpene (4R)(+)-pulegone showed a lower toxicity (LC(50) = 1.7 mg/dm(3)) than M. verticillata or H. multiflora EOs. Dimethyl 2,2-dichlorovinyl phosphate, selected as a positive control, showed an LC(50) of 0.5 mg/dm(3). EOs from M. verticillata and H. multiflora show promise as natural insecticides against houseflies.

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“…From this viewpoint, the antioxidants may have a therapeutic role in the treatment of AlP poisoning (10,12). * The difference between two groups is significant at P < 0.05 ■ There is no significant difference between the treatment and control groups at admission ▲ There is a significant difference between the treatment and control groups 24 h after the onset of poisoning at P < 0.05 Mann-Whitney U-test was used for all the statistical analysis Previous studies showed that vitamin E had a protective role in the in vivo or in vitro toxicity of some poisons through its antioxidant activity and lowering cell death by decreased the levels of MDA, reactive oxygen species production, and lipid peroxidation (18,(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning

Halvaei¹,

Tehrani²,

Soltaninejad³

et al. 2017

Turk J Med Sci

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Background/aim: Aluminum phosphide (AlP) is commonly used as a fumigant in developing countries. Induction of oxidative stress is one of the most important mechanisms of its toxicity. In this regard, and considering that there is no specific antidote for its treatment, the aim of this study was to evaluate the effect of vitamin E in the treatment of acute AlP poisoning. Materials and methods: This was a clinical trial on acute AlP poisoned patients. All patients received supportive treatment. In addition, the treatment group received vitamin E (400 mg/BD/IM). Level of malondialdehyde (MDA) and total antioxidant capacity of plasma were measured. Results: There was no significant difference between the treatment and control groups with regard to demographic, clinical, or paraclinical data or Simplified Acute Physiology Score II (SAPS II ) on admission. Systolic blood pressure significantly increased during the first 24 h in the treatment group (P < 0.05). The plasma MDA level significantly decreased in the treatment group (P < 0.05). Vitamin E administration decreased the necessity (30% vs. 62%, P < 0.05) and duration of intubation and mechanical ventilation (P < 0.05). It significantly reduced the mortality rate in the treatment group compared to the control group (15% vs. 50%, respectively, P < 0.05). Conclusion:Vitamin E along with supportive treatment could have a therapeutic effect in acute AlP poisoning.

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Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats

Cited by 52 publications

References 73 publications

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Insecticidal activity of essential oils from native medicinal plants of Central Argentina against the house fly, Musca domestica (L.)

Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning

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