Methimazole increases H2O2 toxicity in human thyroid epithelial cells

Landex, Nadia L.; Thomsen, Jakob Borup; Kayser, Lars

doi:10.1016/j.acthis.2006.08.001

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Thyroid epithelium: While going through the epithelial histology of disease control group (G-2) we found that 80% of the animals had severe epithelial disruptions which were caused by high dose of MMI. As seen in a previous study, H2O2 is essential for normal thyroid functioning and signaling at low concentrations 17 . MMI when given in such high doses as in our study causes inhibition of G6PD and catalase which in turn imposes oxidative stress due to reactive oxygen species.…”

Section: Discussionsupporting

confidence: 62%

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Histological Study of Commiphora mukul, Withania somnifera and Thyroxine in a Murine Model of Hypothyroidism

Alam¹

2020

Proceedings

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Introduction: Hypothyroidism is a common endocrine disorder not only in developing countries like Pakistan but also in the developed countries having a prevalence of about 4-5%. Thyroxine remains the gold standard treatment for hypothyroidism but due to its adverse effects, newer and safer phyto alternatives are the need of hour. Aims & Objectives: Present study was designed to establish effects of Commiphora mukul, and Withania somnifera on thyroid histology in methimazole induced hypothyroidism in order to compare the effects of these plants on thyroid histology with thyroxine. Place and duration of study: This experimental study was carried out in the animal house of PGMI, Lahore. Total duration of study was 38 days. Material & Methods: 60 rats were sorted in 6 groups with 10 animals each. G-1 was the control group. G-2 received methimazole 60mg/kg/day for 21 days to induce hypothyroidism and left untreated for self recovery & G3-6 were induced with methimazole in the same way. After induction G3-6 were treated for 15 days except group 2, G-3: Commiphora mukul Ethanolic Extract (CMEE) 0.2g/kg/day orally, G4: Withania somnifera Ethanolic Extract (WSEE) 1.4g/kg/day orally. G-5: CMEE 0.2g/kg/day + WSEE 1.4g/kg/day orally. G-6 received the gold standard Thyroxin 0.6ug/100gm BW S/C. Thyroid was excised for histology at the end i.e at day 38. Results: Improved thyroid follicular morphology was seen in all treatment groups in their epithelium, colloid content, reversion of chromatin to normal and decreased nuclear pyknosis. However both extract CMEE & WSEE in combination exhibited equi to greater potential than thyroxine 0.6?g/100gm BW alone. Conclusion: So our study shows that treatment with combination of CMEE 0.2g/kg + WSEE 1.4g/kg orally for 15 days improved thyroid histology significantly which is comparable to gold standard thyroxine proving the potential of this combination to substitute thyroxine.

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Section: Discussionsupporting

confidence: 62%

“…This shows that H2O2 which was previously harmless now became toxic causing epithelial disruption. 14,17 . In the group treated with extracts individually, CMEE group 3 & WSEE group 4; there was partial recovery with only 40% & 50% animals showing normal epithelium respectively while rest of the animals had mild epithelial disruption.…”

Section: Discussionmentioning

confidence: 99%

Histological Study of Commiphora mukul, Withania somnifera and Thyroxine in a Murine Model of Hypothyroidism

Alam¹

2020

Proceedings

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“…During thyroid hormone synthesis, thyroid tissue is exposed to H 2 O 2 making it imperative that protective systems can prevent damage to the gland [ 1 - 5 ]. This tissue protection can be achieved by selenium-dependent products, e.g.…”

Section: Introductionmentioning

confidence: 99%

The role of selenium, vitamin C, and zinc in benign thyroid diseases and of selenium in malignant thyroid diseases: Low selenium levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma

et al. 2008

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“…It is necessary to prevent excess or deficiency of H2O2, anything but optimal levels are linked to several thyroid diseases and disorders, such as congenital hypothyroidism, tumorigenesis, myxedematous cretinism, thyroiditis, and cancer [70,71].…”

Section: Thyroid Hormone Synthesismentioning

confidence: 99%