Methicillin resistant Staphylococcus aureus (MRSA) carriage in different free-living wild animal species in Spain

Porrero, M. Concepción; Mentaberre, Gregorio; Sánchez, Sergio; Fernández-Llario, Pedro; Gómez-Barrero, Susana; Navarro-González, Nora; Serrano, Emmanuel; Casas-Díaz, Encarna; Marco, Ignasi; Fernández-Garayzabal, José-Francisco; Mateos, Ana; Vidal, Dolors; Lavı́n, Santiago; Domı́nguez, Lucas

doi:10.1016/j.tvjl.2013.06.004

Cited by 71 publications

(71 citation statements)

References 24 publications

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“…However, the carriage rates detected in the present study are lower than those reported in different domestic animals such as pigs (36%), small ruminants (from 29 to 64%), donkeys (50%), and rabbits (56%) (26)(27)(28)(29)(30)(31). In contrast to the results obtained for MRSA (17), the detection rate of MSSA in the Eurasian griffon vulture was lower than in the Iberian ibex, red deer, and wild boar, although the differences were not significant (P ϭ 0.057). The lower number of griffon vultures tested might explain the lack of statistical significance.…”

Section: Discussioncontrasting

confidence: 89%

“…Therefore, double sampling (both nares and skin) is recommended in studies dealing with the detection of MSSA carriers. Similar results have been observed for MRSA (17,32). The spa types detected in nasal and skin samples were different in 50% of the positive animals in both samples, indicating that double sampling increases the diversity of spa types found.…”

Section: Discussionsupporting

confidence: 83%

“…The number of individuals per animal species, and the numbers of samples tested are shown in Table 1. Sampling details were previously described (17).…”

Section: Methodsmentioning

confidence: 99%

“…Companion animals are normally colonized by human-related genotypes, although some studies have described colonization factors that determine host specificity (8,13). MRSA detection in freeliving wild animals in Spain has revealed a very low prevalence but genotypes related to livestock and humans (17,18). The genetic diversity of MSSA has been studied in domestic animals, also revealing predominant genotypes in different hosts (19,20).…”

mentioning

confidence: 99%

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Carriage of Staphylococcus aureus by Free-Living Wild Animals in Spain

Porrero

Mentaberre

Sánchez

et al. 2014

Appl Environ Microbiol

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eThe presence of methicillin-susceptible Staphylococcus aureus (MSSA) was analyzed in different free-living wild animals to assess the genetic diversity and predominant genotypes on each animal species. Samples were taken from the skin and/or nares, and isolates were characterized by spa typing, multilocus sequence typing (MLST) and antimicrobial susceptibility testing. The proportion of MSSA carriers were 5.00, 22.93, 19.78, and 17.67% in Eurasian griffon vulture, Iberian ibex, red deer, and wild boar, respectively (P ‫؍‬ 0.057). A higher proportion of isolates (P ‫؍‬ 0.000) were recovered from nasal samples (78.51%) than skin samples (21.49%), but the 9.26% of red deer and 18.25% of wild boar would have been undetected if only nasal samples had been tested. Sixty-three different spa types were identified, including 25 new spa types. The most common were t528 (43.59%) in Iberian ibex, t548 and t11212 (15.79% and 14.04%) in red deer, and t3750 (36.11%) in wild boar. By MLST, 27 STs were detected, of which 12 had not been described previously. The most frequent were ST581 for Iberian ibex (48.72%), ST425 for red deer (29.82%), and ST2328 for wild boar (42.36%). Isolates from Eurasian griffon vulture belong to ST133. Host specificity has been observed for the most frequent spa types and STs (P ‫؍‬ 0.000). The highest resistance percentage was found against benzylpenicillin (average, 22.2%), although most of the S. aureus isolates were susceptible to all antimicrobial tested. Basically, MSSA isolates were different from those MRSA isolates previously detected in the same animal species.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 83%

“…The number of individuals per animal species, and the numbers of samples tested are shown in Table 1. Sampling details were previously described (17).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Carriage of Staphylococcus aureus by Free-Living Wild Animals in Spain

Porrero

Mentaberre

Sánchez

et al. 2014

Appl Environ Microbiol

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“…S. aureus has also been associated with wildlife animals. Studies in Spain demonstrate the presence of ST398 (pig-and human-associated) and ST1 (humanassociated) MRSA isolates harboring the novel mecC methicillin resistance gene (see below) in either red deer, Iberian ibex, wild boar or Eurasian grifon vulture, suggesting a probable human origin of these isolates [12][13][14]. All of these examples represent the high transmission capability of apparently species-speciic S. aureus genetic lineages and urge to the implementation of both molecular epidemiology surveillance and novel infection controls.…”

Section: Frontiers In Staphylococcus Aureus 180 Frontiers In Staphylomentioning

confidence: 99%

Bacteriophage Therapy: An Alternative for the Treatment of Staphylococcus aureus Infections in Animals and Animal Models

Barrera-Rivas¹,

Valle-Hurtado²,

M.González-Lugo³

et al. 2017

Frontiers in Staphylococcus Aureus

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Staphylococcus aureus causes hospital-acquired (HA), community-acquired (CA) and companion animal and livestock-associated (LA) infections. Molecular epidemiology studies suggest that although host speciicity may be associated with speciic genetic lineages, recent human-to-animal and animal-to-human transmissions related to mobile genetic elements have been described. Gene transfers include virulence and antibiotic resistance genes, thus making it diicult to control multidrug resistance S. aureus infections. Bacteriophages (phages) and endolysins, the enzymes responsible for bacterial lysis by phages, are alternatives to the use of antibiotics for the control of S. aureus infections. In this work, we review current advances in the development of phage therapy and the study and design of recombinant endolysins to treat S. aureus infections. Preliminary results of bacteriophage isolation based on molecular epidemiology knowledge show that bacteriophages are speciic of genetic lineages and that this strategy may be used as an approach to isolate and evaluate new bacteriophages for therapy.

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Detection and modeling of Staphylococcus aureus and fecal bacteria in Hawaiian coastal waters and sands

Steadmon,

Takakusagi,

Wiegner

et al. 2024

Water Environment Research

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Microbial pollution of recreational waters leads to millions of skin, respiratory, and gastrointestinal illnesses globally. Fecal indicator bacteria (FIB) are monitored to assess recreational waters but may not reflect the presence of Staphylococcus aureus, a global leader in bacterial fatalities. Since many community‐acquired S. aureus skin infections are associated with high recreational water usage, this study measured and modeled S. aureus, methicillin‐resistant S. aureus (MRSA), and FIB (Enterococcus spp., Clostridium perfringens) concentrations in seawater and sand at six beaches in Hilo, Hawai‘i, USA, over 37 sample dates from July 2016 to February 2019 using culturing techniques. Generalized linear models predicted bacterial concentrations with physicochemical and environmental data. Beach visitors were also surveyed on their preferred activities. S. aureus and FIB concentrations were roughly 6–78 times higher at beaches with freshwater discharge than at those without. Seawater concentrations of Enterococcus spp. were positively associated with MRSA but not S. aureus. Elevated S. aureus was associated with lower tidal heights, higher freshwater discharge, onsite sewage disposal system density, and turbidity. Regular monitoring of beaches with freshwater input, utilizing real‐time water quality measurements with robust modeling techniques, and raising awareness among recreational water users may mitigate exposure to S. aureus, MRSA, and FIB.Practitioner Points Staphylococcus aureus and fecal bacteria concentrations were higher in seawater and sand at beaches with freshwater discharge. In seawater, Enterococcus spp. positively correlated with MRSA, but not S. aureus. Freshwater discharge, OSDS density, water turbidity, and tides significantly predicted bacterial concentrations in seawater and sand. Predictive bacterial models based upon physicochemical and environmental data developed in this study are readily available for user‐friendly application.

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Methicillin resistant Staphylococcus aureus (MRSA) carriage in different free-living wild animal species in Spain

Cited by 71 publications

References 24 publications

Carriage of Staphylococcus aureus by Free-Living Wild Animals in Spain

Carriage of Staphylococcus aureus by Free-Living Wild Animals in Spain

Bacteriophage Therapy: An Alternative for the Treatment of Staphylococcus aureus Infections in Animals and Animal Models

Detection and modeling of Staphylococcus aureus and fecal bacteria in Hawaiian coastal waters and sands

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