Methicillin-resistant Staphylococcus-aureus-associated glomerulonephritis on the decline: decreased incidence since the 1990s

Abstract

We believe that bacterial-infection-associated glomerulonephritis (GN), so-called methicillin-resistant Staphylococcus aureus (MRSA)-GN, was exterminated in Japan. The control of bacterial infection is the most important part of infection-associated GN. In 1990s Japan, hospital-associated MRSA (HA-MRSA) caused MRSA-GN outbreaks. On the other hand, MRSA-GN incidence has been quite limited since 2000. This epidemiological transition suggests that antibacterial therapies and health programs for HA-MRSA infection in Japan were effective against MRSA-GN. Moreover, it appears that staphylococcal superantigens act in the pathogenesis of GN. The change of superantigen production might have influenced to the disappearance of MRSA-GN. If HA-MRSA-producing superantigen outbreaks occur in developing countries, our experience in Japan can provide guiding principles for preventing and eradicating GN.

Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA)

“…Over the last decade, the attention paid to meticillin-resistant Staphylococcus aureus (MRSA), both in the scientific literature and the lay press, has been a driver of many of the initiatives associated with the declining burden of hospital-acquired MRSA infections [1][2][3]. However, since the early 2000s, community-acquired MRSA (CA-MRSA) has disseminated rapidly throughout many of the industrialised regions of the world [4][5][6].…”