Methicillin-resistant<i>Staphylococcus aureus</i>in Horses and Horse Personnel, 2000–2002

Weese, J. Scott; Archambault, Marie; Willey, Barbara M.; Hearn, Pasco; Kreiswirth, Barry N.; Saïd-Salim, B.; McGeer, Allison; Likhoshvay, Yekaterina; Prescott, John F.; Low, Donald E.

doi:10.3201/eid1103.040481

Cited by 211 publications

(89 citation statements)

References 33 publications

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“…MRSA has also been identified as an emerging disease in horses (Weese et al, 2005a;Weese et al, 2005b;Weese et al, 2006), which might act as a reservoir of rare strains for transmission to humans (Baptiste et al, 2005). The isolation of MRSA from two horses in Canada led to a larger study which revealed the colonisation of 79 hospitalised horses and also of 27 people involved in caring for these animals, strongly suggestive of frequent transmission between horses and humans (Weese et al, 2005b).…”

Section: E Horse Associated Mrsamentioning

confidence: 99%

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Gaze

O’Neill

Wellington

et al. 2008

Advances in Applied Microbiology

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Section: E Horse Associated Mrsamentioning

confidence: 99%

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Gaze

O’Neill

Wellington

et al. 2008

Advances in Applied Microbiology

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“…The implications of humans passing S. aureus to horses and other pets are important because carriage S. aureus in healthy people are becoming increasingly virulent and resistant (Dufour et al, 2002;Gopal Rao et al, 2007). This leads to animal infections that require more complex antibiotic regimes (Loeffler et al, 2005, Weese et al, 2005, and in return, animal contact could become a potential risk to immunocompromised humans.…”

Section: Human (N535)mentioning

confidence: 99%

“…MRSA is also of concern in animals such as dogs, horses and pigs (Loeffler et al, 2005, Weese et al, 2005Huijsdens et al, 2006). These animals could act as a reservoir of human isolates (this is likely for dogs), or could represent an opportunity for the evolution of increasingly pathogenic and resistant strains.…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray

2008

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Staphylococcus aureus is a commensal and pathogen of several mammalian species, particularly humans and cattle. We aimed to (i) identify S. aureus genes associated with host specificity, (ii) determine the relatedness of human and animal isolates, and (iii) identify whether human and animal isolates typically exchanged mobile genetic elements encoding virulence and resistance genes. Using a well-validated seven-strain S. aureus microarray, we compared 56 UK S. aureus isolates that caused infection in cows, horses, goats, sheep and a camel with 161 human S. aureus isolates from healthy carriers and community acquired infections in the UK. We had previously shown that human isolates are clustered into ten dominant and a few minor lineages, each with unique combinations of surface proteins predicted to bind to human proteins. We found that the animal-associated S. aureus clustered into ten lineages, with 61 % assigned to four lineages, ST151, ST771, ST130 and ST873, that were unique to animals. The majority of bovine mastitis was caused by isolates of lineage ST151, ST771 and ST97, but a few human lineages also caused mastitis. S. aureus isolated from horses were more likely to cluster into humanassociated lineages, with 54 % of horse-associated S. aureus assigned to the human clusters CC1, CC8 and CC22; along with the presence of some multi-drug resistant strains, this suggests a human origin. This is the most comprehensive genetic comparison of human versus animal S. aureus isolates conducted, and because we used a whole-genome approach we could estimate the key genes with the greatest variability that are associated with host specificity. Several genes conserved in all human isolates were variable or missing in one or more animal lineages, including the well-characterized lineage specific genes fnbA, fnbB and coa. Interestingly, genes carried on mobile genetic elements (MGEs) such as chp, scn and sak were less common in animal S. aureus isolates, and bap was not found. There was a lot of MGE variation within lineages, and some evidence that exchange of MGEs such as bacteriophage and pathogenicity islands between animal and human lineages is feasible, but there was less evidence of antibiotic resistance gene transfer on the staphylococcal cassette chromosomes (SCC) or plasmids. Surprisingly, animal lineages are closely related to human lineages and only a handful of genes or gene combinations may be responsible for host specificity.

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“…It was irst found in infected horses in Ireland and thereafter reported in the Netherlands, Austria, and Germany [226][227][228]. Many MRSA isolates from Canada showed ST8-SCCmec IV-t064 genotype [93]. They were designated as a Canadian epidemic MRSA-5 (CMRSA-5) and were very close to a human clone, USA500.…”

Section: Equine Mrsamentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products

Chon¹,

Sung²,

Khan³

2017

Frontiers in Staphylococcus Aureus

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Methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern in companion and food-producing animals. The presence of multidrug-resistance with a wide range of extracellular enterotoxin genes, virulence factors, and Panton-Valentine leukocidin (pvl) cytotoxin genes confer life-threatening traits on MRSA and makes them highly pathogenic and diicult to treat. Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, catle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and ish).

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Methicillin-resistantStaphylococcus aureusin Horses and Horse Personnel, 2000–2002

Abstract: Methicillin-resistant Staphylococcus aureus was isolated from horses and horse personnel in a pattern suggestive of interspecies transmission of a human-origin clone.

Cited by 211 publications

References 33 publications

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray

Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products

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