Methanolic extract of <i>Moringa oleifera</i> leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats

Olayaki, Luqman Aribidesi; Irekpita, Justice E; Yakubu, Musa Toyin; Ojo, Opeolu O.

doi:10.1515/jbcpp-2014-0129

Cited by 56 publications

(44 citation statements)

References 34 publications

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“…These hypoglycemic effects have been tested with doses of seed powder (50–100 mg/kg body weight) in diabetes mellitus, where in decreases in fasting blood sugar and serum hemoglobin A 1c compared with positive controls have been observed [46]. Previous studies suggest that kaempferol stimulates glucose uptake in the rat soleus muscle via the PI3K and PKC pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Olayaki et al, (2015) observed that oral administration of extract of M. oleifera significantly reduces blood glucose concentration and inhibits weight loss in alloxan-induced diabetic rats. Another previous study showed a significant increase in the body weight of rats treated with 50 mg and 100 mg of seed powder [46]. The increase in weight may be due to the content of seed powder, specifically essential amino acids and vitamins A, B, C and E. In addition, antioxidants and antimicrobial compounds (phenols, tannins, alkaloids and cumarins) can act as growth promoters [48].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Moringa oleifera consumption on diabetic rats

Villarruel-López

Mora

Vázquez-Paulino

et al. 2018

BMC Complement Altern Med

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BackgroundTherapeutic use of leaves of M. oleifera has been evaluated in diabetes because of its possible capacity to decrease blood glucose and lipids concentration after ingestion, as result of the polyphenols content and others compounds. Nevertheless most results have been obtain from leaf extract, therefore this study would use leaf powder as the regular way of consumption of population to know effects over toxicity glucose, triglycerides, cholesterol, corporal weight, and predominant groups of microbiota.MethodsPowdered leaf was administrated in different doses to know toxicity and genotoxicity using LD50 and micronuclei assay. Hyperglycemia was induced by alloxan on Sprague Dawley rats. Glucose and body weight were measured once a week meanwhile cholesterol and triglycerides were analyzed at the end of the study by commercial kits. Different organs were examined by hematoxylin-eosin technique. Lactic acid bacteria and Enterobacteriaceae were enumerated from stool samples.ResultsThe tested doses revealed no lethal dose and no significant differences in genotoxicity parameter. The consumption of the leaves showed a hypoglycemic effect (< 250 mg/dL in diabetic M. oleifera treated group), however in corporal weight showed an increased (> 30 g over no M. oleifera treated groups). There was no change in enumeration of lactic acid bacteria (8.4 CFU/g) but there were differences in the predominance of type of lactobacillus and enterobacteria enumeration.ConclusionsThese results help to increase information over the most popular use of M. oleifera and its safety. However there are needed more studies over the hypoglycemic mechanisms and effects over intestinal microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera consumption on diabetic rats

Villarruel-López

Mora

Vázquez-Paulino

et al. 2018

BMC Complement Altern Med

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“…Moreover, administration of methanolic extract of moringa leaves at 300 and 600 mg/kg to alloxan‐induced diabetic rats improved glucose tolerance by 56% and 57%, respectively. The same doses of the extract also decreased blood glucose concentration by 76% and 84%, respectively in the diabetic rats after 6 weeks of administration (Olayaki, Irekpita, Yakubu, & Ojo, ). In a similar study, the effect of daily administration of aqueous extract of moringa leaves at a dose of 200 mg/kg on fasting blood glucose was investigated in STZ‐induced diabetic rats.…”

Section: Animal Studiesmentioning

confidence: 90%

“…In a study of diabetic mice, moringa leaf extract improved insulin sensitivity by stimulating insulin‐dependent Akt pathway and upregulating glucose transporter GLUT4 expression in the muscles (Attakpa et al, ). In addition, treatment of diabetic rats with moringa leaf extract improved glycogen synthase activities, glycogen contents, and glucose uptake in the liver and muscles (Olayaki et al, ). In another study, aqueous extract of moringa leaves showed hypoglycemic property by decreasing expression of pyruvate carboxylase enzyme in the liver and by regenerating damaged pancreatic β‐cells and hepatocytes through its antioxidant activities (Abd El Latif et al, ).…”

Section: Possible Mechanismsmentioning

confidence: 99%

Moringa oleifera and glycemic control: A review of current evidence and possible mechanisms

Ahmad

Khan

Blundell

2019

Phytotherapy Research

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Maintaining glycemic control in diabetes and prediabetes is necessary to prevent many health complications and mortality. Although different hypoglycemic drugs are used for this purpose, there is still a growing interest in the use of medicinal plants due to their low price, easy availability, and fewer or no side effects. Moringa (Moringa oleifera Lam.) is a medicinal plant that has been traditionally used in the management of diabetes. This review aims to present the existing literature published until February 2019 on the role of moringa leaves in glycemia and their physiological mechanisms. In the conducted studies, moringa leaves have shown to reduce glycemia, without causing any adverse effects. The proposed mechanisms for reducing glycemia include inhibition of α‐amylase and α‐glucosidase activities, increased glucose uptake in the muscles and liver, inhibition of glucose uptake from the intestine, decreased gluconeogenesis in the liver, and increased insulin secretion and sensitivity. However, these studies are limited in numbers and mostly conducted in animals, in vitro and in vivo. Therefore, long‐term human studies are required to determine the hypoglycemic effect of moringa leaves, their physiological mechanisms, active ingredients, and safety. Overall, this review provides evidence that moringa leaves have the possibility to be used as a glycemic control agent in diabetes and prediabetes.

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“…It was observed that oral administration of extract of Moringa oleifera significantly reduces blood glucose concentration and inhibits weight loss (Olayaki et al, 2015). Another study showed a significant increase in the body weight, specifically essential amino acids and vitamins.…”

Section: Discussionmentioning

confidence: 99%

Influence of Moringa oleifera flaxseed oil and atorvastatin on hyperlipidemic male albino rats

Abdelhalim

Hegazi

El-Bagoury

2019

Journal of Cancer and Biomedical Research

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The main aim of this study was to investigate the beneficial effects of lipitor (LIP), a commercial brand name of atorvastatin drug, flaxseed oil (FSO) and Moringa oleifera oil (MO), extract (ME) or meal (Mm) alone or in combination on hyperlipidemia induced in adult male albino rats. Rats were fed for 2 weeks on basal diet as a negative control group or fed on high fat diet (HFD) and a weekly dose of triton X-100 to induce hyperlipidemia as positive controls. The latter group was treated with: LIP, LIP + FSO, LIP + ME, FSO, FSO + ME, ME, MO or Mm for 4 weeks. At the end of the experiment, the livers were quickly excised and processed for analyzing the antioxidative enzymes activities including total superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR) and malondialdehyde (MDA). Feeding on MO and ME) showed no effects on the body weight or on antioxidative enzyme activities. Feeding on FSO, however, induced only increase in the body weight. ME of dry leaves and roots showed a decrease in the body weight and improved antioxidative enzymes activities. These effects of FSO, ME and MO on the body weight of rats may be attributed to captivity and reduction of the energy expenditure, while their marked effects on the antioxidative enzyme activity may need longer time of treatments. These results indicate that Moringa oleifera can be used in packed food supplement products.

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Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats

Abstract: These results showed that hypoglycemic effects of MOLE might be mediated through the stimulation of insulin release leading to enhanced glucose uptake and glycogen synthesis.

Cited by 56 publications

References 34 publications

Effect of Moringa oleifera consumption on diabetic rats

Effect of Moringa oleifera consumption on diabetic rats

Moringa oleifera and glycemic control: A review of current evidence and possible mechanisms

Influence of Moringa oleifera flaxseed oil and atorvastatin on hyperlipidemic male albino rats

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