Effect of Moringa oleifera consumption on diabetic rats

Abstract

BackgroundTherapeutic use of leaves of M. oleifera has been evaluated in diabetes because of its possible capacity to decrease blood glucose and lipids concentration after ingestion, as result of the polyphenols content and others compounds. Nevertheless most results have been obtain from leaf extract, therefore this study would use leaf powder as the regular way of consumption of population to know effects over toxicity glucose, triglycerides, cholesterol, corporal weight, and predominant groups of microbiota.MethodsPowdered leaf was administrated in different doses to know toxicity and genotoxicity using LD50 and micronuclei assay. Hyperglycemia was induced by alloxan on Sprague Dawley rats. Glucose and body weight were measured once a week meanwhile cholesterol and triglycerides were analyzed at the end of the study by commercial kits. Different organs were examined by hematoxylin-eosin technique. Lactic acid bacteria and Enterobacteriaceae were enumerated from stool samples.ResultsThe tested doses revealed no lethal dose and no significant differences in genotoxicity parameter. The consumption of the leaves showed a hypoglycemic effect (< 250 mg/dL in diabetic M. oleifera treated group), however in corporal weight showed an increased (> 30 g over no M. oleifera treated groups). There was no change in enumeration of lactic acid bacteria (8.4 CFU/g) but there were differences in the predominance of type of lactobacillus and enterobacteria enumeration.ConclusionsThese results help to increase information over the most popular use of M. oleifera and its safety. However there are needed more studies over the hypoglycemic mechanisms and effects over intestinal microbiota.

Moringa oleiferaand glycemic control: A review of current evidence and possible mechanisms

“…In another study, consumption of moringa leaf powder at 50 mg/day by alloxan‐induced diabetic rats for 8 weeks showed a significant decrease in blood glucose concentration compared with untreated diabetic rats (Villarruel‐Lopez et al, ). In the same study, different doses of moringa leaves (100, 250, and 500 mg/kg) showed no adverse effects (e.g., possible change in food intake, diarrhea, decreased activity, unusual body growth, bleeding, or death) in the rats; in addition, no prominent changes were found in genotoxicity parameters (Villarruel‐Lopez et al, ). Similarly, treatment with ethanolic extract of moringa leaves at a dose of 150 mg kg −1 day −1 for 5 weeks significantly decreased fasting blood glucose level from 483 to 312 mg/dl in Type 2 diabetic mice compared with control group (Tang et al, ).…”

“…In a recent study, administration of ethyl acetate extract of moringa leaves at a dose of 200 mg/kg to streptozotocin (STZ)-induced diabetic rats for 30 days significantly decreased their blood glucose and glycosylated hemoglobin (HbA1c) levels compared with control group (Bamagous et al, 2018). In another study, consumption of moringa leaf powder at 50 mg/day by alloxan-induced diabetic rats for 8 weeks showed a significant decrease in blood glucose concentration compared with untreated diabetic rats (Villarruel-Lopez et al, 2018). In the same study, different doses of moringa leaves (100, 250, and 500 mg/kg) showed no adverse effects (e.g., possible change in food intake, diarrhea, decreased activity, unusual body growth, bleeding, or death) in the rats; in addition, no prominent changes were found in genotoxicity parameters (Villarruel-Lopez et al, 2018).…”

Effect of Feeding of Moringa oleifera Seed Meal as a New Protein Source on Performance, Digestibility and Blood Constituents of Male Goats Under Desert Conditions

“…It contains large amounts of various phytochemicals including phenolics, tannins, saponin, glucosinolates, flavonoids, flavonol glycosides, quercetin, kaempferol, phytate, and lectins (Maizuwo et al, 2017;Atta et al, 2017;. These phytochemicals help in treating various diseases as antidiarrheal, antiulcerative, and hepato-and nephroprotective, antidiabetic and anticancer effects (Gopalakrishnan et al, 2016;Shalaby et al, 2016;Atta et al, 2017Atta et al, , 2018Villarruel-López et al, 2018;Hagoel et al, 2019). All parts of MO tree are edible.…”

Anti-diabetic effect of moringa oleifera extract on parotid gland of albino rats

“…Also A. Villarruel-López et al, 2018 reported that the beneficial effects of moringa leaves are due to its polyphenols content and others useful compounds, 6 .…”

“…Moringa oleifera (MO) "drum stick tree" belongs to the Moringaceae family. This tree is essential because it has medicinal uses for its flowers, pods and leaves, 6 . Moringa leaf is a prospective source of natural antioxidants such as total phenolics and antioxidant vitamins A, C and E, polyphenol oxidase, ascorbic acid oxidase, and catalase, 7 .…”