Methamphetamine pre-exposure induces steeper escalation of methamphetamine self-administration with consequent alterations in hippocampal glutamate AMPA receptor mRNAs

Chojnacki, Michael R.; Jayanthi, Subramaniam; Cadet, Jean Lud

doi:10.1016/j.ejphar.2020.173732

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Prior experience with METH influences the responsivity of subsequent METH SA to pharmacological regulation. For example, there is evidence that preexposure to METH has a modulatory effect on later METH SA, including the dopaminergic mechanisms that govern such behavior (Chojnacki et al, 2020;Culbertson et al, 2009;Kazahaya et al, 1989;Lorrain et al, 2000;Mcfadden et al, 2013;McFadden et al, 2015McFadden et al, , 2012Segal et al, 2003;Vezina et al, 1999). Further, the level per se of prior METH experience can differentially modulate subsequent METH SA response: a comparison of METH experienced rats trained under restricted access versus extended access revealed that subjects taking METH under extended access conditions were more sensitive to the effects of aripiprazole, a dopamine D2 receptor partial agonist, on METH SA (Wee et al, 2007).…”

Section: Figure 1 Experience-dependent Engagement Of the Dorsal Striatummentioning

confidence: 99%

Experience-dependent sex differences in the role of dorsal striatal dopamine D1 receptor activity in methamphetamine self-administration revealed by a novel TREND model

Madhuranthakam,

Job

2024

Preprint

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BACKGROUNDThe role of dorsal striatal dopamine D1 receptor systems in the mechanism of methamphetamine self-administration (METH SA), and sex differences in this role, are unclear. We hypothesized that this role would be sex and METH experience-dependent. Because prior experience regulates subsequent effects of drugs, we developed a novel model to account for this interaction, termed the TREND model (Time-Related-Experience-Normalized-Dynamics) for drug SA analysis. We tested our hypothesis by comparing results from the new TREND model and the current model.METHODSFor model validation, we reanalyzed previous data (Job et al., 2020) with the aim of determining which model (current or TREND) was more effective as an analytical tool. We compared variables from each model with the effect of Clozapine-N-Oxide (CNO, chemogenetic ligand) on METH SA. We employed regression analysis, median split, ANOVA to see which could reveal sex and experience dependency of dorsal striatal dopamine D1 receptor system.RESULTSThe current model variables were unrelated to CNO effect, with no sex differences in these relationships. TREND model revealed new variables that were unrelated to current variables but related to CNO effect on METH in males and females, with sex differences in these relationships. TREND, but not the current model, detected sex differences when comparing males and females with prior high, but not low, behavioral response variables.CONCLUSIONSTREND model is more sensitive than the current model for detecting experience-dependent sex differences in the role of the dorsal striatal dopamine D1 receptor systems in the mechanism of METH SA.

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Section: Figure 1 Experience-dependent Engagement Of the Dorsal Striatummentioning

confidence: 99%

Experience-dependent sex differences in the role of dorsal striatal dopamine D1 receptor activity in methamphetamine self-administration revealed by a novel TREND model

Madhuranthakam,

Job

2024

Preprint

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“…Patients also show changes in learning and memory functions (Shukla and Vincent, 2021) that are subserved by the hippocampus (Golsorkhdan et al, 2020). The substrates for METH-associated cognitive disturbances might include epigenetic modifications, altered gene expression, changes in synaptic plasticity, and dysfunctional neurotransmission (Chojnacki et al, 2020;Golsorkhdan et al, 2020;Shukla and Vincent, 2021). This line of reasoning suggests that METH might influence the expression of genes including cell adhesion molecules (CAMs) that participate in regulating hippocampal synaptic plasticity (Cotman et al, 1998;Gnanapavan and Giovannoni, 2013) and other drug-induced neuroadaptions during addictive processes (Muskiewicz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Compulsive methamphetamine self-administration in the presence of adverse consequences is associated with increased hippocampal mRNA expression of cellular adhesion molecules

Munoz

Jayanthi²,

Ladenheim³

et al. 2023

Front. Mol. Neurosci.

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Methamphetamine (METH) is a popular but harmful psychostimulant. METH use disorder (MUD) is characterized by compulsive and continued use despite adverse life consequences. METH users experience impairments in learning and memory functions that are thought to be secondary to METH-induced abnormalities in the hippocampus. Recent studies have reported that about 50% of METH users develop MUD, suggesting that there may be differential molecular effects of METH between the brains of individuals who met criteria for addiction and those who did not after being exposed to the drug. The present study aimed at identifying potential transcriptional differences between compulsive and non-compulsive METH self-administering male rats by measuring global gene expression changes in the hippocampus using RNA sequencing. Herein, we used a model of METH self-administration (SA) accompanied by contingent foot-shock punishment. This approach led to the separation of animals into shock-resistant rats (compulsive) that continued to take METH and shock-sensitive rats (non-compulsive) that suppressed their METH intake in the presence of punished METH taking. Rats were euthanized 2 h after the last METH SA plus foot-shock session. Their hippocampi were immediately removed, frozen, and used later for RNA sequencing and qRT-PCR analyses. RNA sequencing analyses revealed differential expression of mRNAs encoding cell adhesion molecules (CAMs) between the two rat phenotypes. qRT-PCR analyses showed significant higher levels of Cdh1, Glycam1, and Mpzl2 mRNAs in the compulsive rats in comparison to non-compulsive rats. The present results implicate altered CAM expression in the hippocampus in the behavioral manifestations of continuous compulsive METH taking in the presence of adverse consequences. Our results raise the novel possibility that altered CAM expression might play a role in compulsive METH taking and the cognitive impairments observed in MUD patients.

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The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference

Modaberi

Amirteymori

Mesgar

et al. 2023

Pharmacology Biochemistry and Behavior

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Methamphetamine pre-exposure induces steeper escalation of methamphetamine self-administration with consequent alterations in hippocampal glutamate AMPA receptor mRNAs

Cited by 4 publications

References 31 publications

Experience-dependent sex differences in the role of dorsal striatal dopamine D1 receptor activity in methamphetamine self-administration revealed by a novel TREND model

Experience-dependent sex differences in the role of dorsal striatal dopamine D1 receptor activity in methamphetamine self-administration revealed by a novel TREND model

Compulsive methamphetamine self-administration in the presence of adverse consequences is associated with increased hippocampal mRNA expression of cellular adhesion molecules

The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference

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