Experience-dependent sex differences in the role of dorsal striatal dopamine D1 receptor activity in methamphetamine self-administration revealed by a novel TREND model
InduMithra Madhuranthakam,
Martin O Job
Abstract:BACKGROUNDThe role of dorsal striatal dopamine D1 receptor systems in the mechanism of methamphetamine self-administration (METH SA), and sex differences in this role, are unclear. We hypothesized that this role would be sex and METH experience-dependent. Because prior experience regulates subsequent effects of drugs, we developed a novel model to account for this interaction, termed the TREND model (Time-Related-Experience-Normalized-Dynamics) for drug SA analysis. We tested our hypothesis by comparing result… Show more
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