Methadone-Induced Toxic Leukoencephalopathy: Diagnosis and Follow-up by Magnetic Resonance Imaging Including Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Maps

Cerase, Alfonso; Leonini, Sara; Bellini, Matteo; Chianese, Giuseppe; Venturi, Carlo

doi:10.1111/j.1552-6569.2010.00530.x

Cited by 27 publications

(36 citation statements)

References 9 publications

(22 reference statements)

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“…Methadone-induced brain toxic leukoencephalopathy is reported in several cases with decreased level of consciousness [Salgado et al, 2010; Cerase et al, 2011; Bileviciute-Ljungar et al, 2014]. In addition, there is a cerebellar and basal ganglia involvement in methadone overdose as well [Corre et al, 2013].…”

Section: Discussionmentioning

confidence: 99%

Methadone use in a male with the FMRI premutation and FXTAS

Muzar

Lozano

Schneider

et al. 2015

American J of Med Genetics Pt A

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The fragile X-associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene. Recent reports of environmental toxins appear to worsen the progression of FXTAS. Here we present a case of male adult with FXTAS and a long history of methadone use. The patient shows a faster progression in both symptoms of disease and MRI changes compared to what is typically seen in FXTAS. There has been no research regarding the role of narcotics in onset, progression, and severity of FXTAS symptoms. However, research has shown that narcotics can have a negative impact on several neurodegenerative diseases, and we hypothesize that in this particular case, methadone may have contributed to a faster progression of FXTAS as well as exacerbating white matter disease through RNA toxicity seen in premutation carriers.

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Section: Discussionmentioning

confidence: 99%

Methadone use in a male with the FMRI premutation and FXTAS

Muzar

Lozano

Schneider

et al. 2015

American J of Med Genetics Pt A

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“…The results of Li et al (2016) suggested that methadone damages the integrity of the white matter of long‐time consumer of methadone in a dose‐dependent pattern . The radiological studies revealed that methadone in high concentration and long‐term consumption influences on the structure of the brain in the cerebellum, basal ganglia, and deep white matter of the cerebral hemispheres . For methadone, two signal paths have been suggested: one for binding to opioid receptors and another for acting as an antagonist in NMDR .…”

Section: Resultsmentioning

confidence: 99%

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

Ahmeda

Zangeneh

Mansooridara

et al. 2020

Applied Organom Chemis

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Metallic nanoparticles have gained significant attention in the area of biomedical technology. Because of its high surface area, metallic nanoparticles are being widely used in various fields including the medical and engineering sciences. One of the valuable applications of metallic nanoparticles especially copper, zinc, and iron nanoparticles is increasing the physiological function of central nervous system. Besides, Iranian people are using the Salvia chloroleuca for neuroprotective properties. In the present research, iron nanoparticles were biosynthesized by S. chloroleuca leaf aqueous extract as reducing and stabilizing agents. Also, we revealed the protective effect of FeNPs in methadone‐treated PC12 cells. FeNPs were characterized and analyzed using common nanotechnology techniques including FT‐IR, UV–Vis. spectroscopy; EDS, TEM, and FE‐SEM. TEM and FE‐SEM images revealed a uniform spherical morphology for FeNPs. In the biological part of the current study, the both treatments of FeNPs significantly (p ≤ 0.01) reduced the cell cytotoxicity and cell death index as well as increased the cell viability and cell proliferation in methadone‐treated PC12 cells. In these treatments, mitochondrial membrane potential significantly (p ≤ 0.01) increased compared to methadone‐induced PC12 cells. DPPH free radical scavenging test was did to evaluate the antioxidant potentials of FeCl3, S. chloroleuca, and FeNPs. DPPH test indicated similar antioxidant activities for S. chloroleuca, FeNPs, and butylated hydroxytoluene. In current experiment, we concluded that iron nanoparticles biosynthesized by S. chloroleuca leaf aqueous extract suppressed methadone‐induced cell death in a dose‐dependent manner in PC12 cells.

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“…Numerous other drugs of abuse have been associated with toxic leukoencephalopathy to a lesser extent. These include the psychoactive drug 2C-E "Europa" [15], oxycodone [24], and methadone [25,26].…”

Section: Discussionmentioning

confidence: 99%

Methylenedioxymethamphetamine (MDMA)-induced toxic leukoencephalopathy: a case report

Salem

Barton

Ali

et al. 2017

Psychiatry and Clinical Psychopharmacology

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In recent years, ecstasy has become a very popular recreational drug. To date, very little data is available regarding its toxic side effects. Specifically, reports relating ecstasy use to the clinical diagnosis of leukoencephalopathy are quite rare. In this report, we present an interesting case of a 33-year-old female with a recent history of ecstasy abuse who presented with delirium and cognitive impairment. In addition, we review published case reports that explore the connection between MDMA and leukoencephalopathy.ARTICLE HISTORY

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Methadone-Induced Toxic Leukoencephalopathy: Diagnosis and Follow-up by Magnetic Resonance Imaging Including Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Maps

Cited by 27 publications

References 9 publications

Methadone use in a male with the FMRI premutation and FXTAS

Methadone use in a male with the FMRI premutation and FXTAS

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

Methylenedioxymethamphetamine (MDMA)-induced toxic leukoencephalopathy: a case report

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