Metformin Use in Children and Adolescents with Prediabetes

Khokhar, Aditi; Umpaichitra, Vatcharapan; Chin, Vivian; Perez-Colon, Sheila

doi:10.1016/j.pcl.2017.08.010

Cited by 44 publications

(38 citation statements)

References 57 publications

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“…Among minority adolescents in the United States, those with a laboratory measured HbA1c > 6% (42 mmol/mol) have more than double the rate of progression to diabetes than those with an HbA1c 5.7% to 6% (39‐42 mmol/mol) Only lifestyle change, with decreased caloric intake and increased physical activity has been shown to be effective for adolescents with pre‐diabetes . There is currently no evidence base for the use of medications, such as metformin, for the treatment of prediabetes in adolescents and the low progression rate to diabetes in this population indicates that many adolescents would be unnecessarily treated. …”

Section: Definition Classification and Characteristics Of Youth‐onsmentioning

confidence: 99%

“…66 • Only lifestyle change, with decreased caloric intake and increased physical activity has been shown to be effective for adolescents with pre-diabetes. 67 There is currently no evidence base for the use of medications, such as metformin, for the treatment of prediabetes in adolescents and the low progression rate to diabetes in this population indicates that many adolescents would be unnecessarily treated.…”

Section: Uncertainties Of Classificationmentioning

confidence: 99%

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ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 diabetes mellitus in youth

et al. 2018

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Section: Definition Classification and Characteristics Of Youth‐onsmentioning

confidence: 99%

Section: Uncertainties Of Classificationmentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 diabetes mellitus in youth

et al. 2018

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“…La disminución de peso y la acti vidad fí sica han mostrado su efecti vidad disminuyendo la insulina en ayunas y por ende mejorando la RI 41 . En cuanto a lo farmacológico, el uso de la metf ormina mejora los marcadores de sensibilidad a la insulina y reduce el IMC en niños y adolescentes con RI o pre-diabetes 42 .…”

Section: Discussionunclassified

Obesidad, resistencia a la insulina y diabetes mellitus tipo 2 en adolescentes

et al. 2018

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J. Obesidad, resistencia a la insulina y diabetes mellitus tipo 2 en adolescentes. An Fac med. 2018;79(3):200-5. DOI: http://dx.doi.org/10.15381/anales. v79i3.15311 Resumen Introducción. La obesidad está considerada como un problema de salud pública. Su presencia a edades tempranas implica una obligación de identificar la aparición de complicaciones como resistencia a la insulina y diabetes mellitus (DM). Métodos. Estudio observacional, descriptivo y transversal. Participaron 1206 mujeres adolescentes. Se definió la obesidad con valores de IMC ≥ 95p según la OMS. Se determinó niveles séricos de insulina, glucosa y perfil lipídico. Se usó el Homeostasis Model of Assesmente Index (HOMA-I), mediante la ecuación de Matthews con el valor ≥ 3,16 para definir resistencia a la insulina (RI). Para las dislipidemias: hipercolesterolemia ≥ 200 mg/dL, bajo C-HDL ≤ 40 mg/dL, alto C-LDL ≥ 130 mg/dL e hipetrigliceridemia ≥ 130 mg/dL. A las adolescentes obesas con RI se les hizo una prueba de tolerancia oral a la glucosa (PTG): glicemia de 140 a 199 mg/dL intolerantes a la glucosa y ≥ 200 mg/dL diabéticas. Resultados. El 25,1% (303) de la población fue obesa; 246 adolescentes obesas participaron de la evaluación bioquímica, 28,1% (69) de ellas presentaron RI. En las adolescentes obesas con y sin RI, el promedio de las variables bioquímicas en las primeras fueron mayores, siendo estas diferencias significativas estadísticamente, salvo el C-HDL. Diferencias entre la prevalencia de dislipidemias fueron significativas a excepción del C-HDL. La RI presentó un OR de 10,9 (IC 5,6), 12,1 (IC 4,9-30,1), y 7,6 (IC 3-19,5) con la hipertrigliceridemia, hipercolesterolemia y C-LDL alto. La PTG mostró un 3,3% de intolerantes y ninguna diabética. Conclusiones. El 28,1% (69) de adolescentes obesas presentaron RI; ninguna participante del estudio presentó DM. Palabras clave: Obesidad; Resistencia a la insulina; Diabetes mellitus; Adolescente; Dislipidemias Abstract Introduction. Obesity is considered a public health problem. Its presence at an early age implies an obligation to identify the onset of complications such as insulin resistance and diabetes mellitus (DM). Methods. Observational, descriptive and transversal study. Participated 1206 teenage women. Obesity was defined with BMI values ≥95p according WHO. Serum levels of insulin, glucose and lipid profile were determined. The Homeostasis Model of Assesment Index (HOMA-I) was used, using the Matthews equation with the value ≥ 3,16 to define insulin resistance (RI). For dyslipidemias: hypercholesterolemia ≥ 200 mg/dL, low HDL-C ≤ 40 mg/dL, high C-LDL ≥ 130 mg / dL and hypetriglyceridemia ≥ 130 mg/dL. The obese teenagers with RI underwent an oral glucose tolerance test (PTG): glycemia of 140 to 199 mg / dL intolerant to glucose and ≥ 200 mg/dL as diabetic. Results 25,1% (303) of the population was obese; 246 obese adolescents participated in the biochemical evaluation, 28,1% (69) of them presented RI. In the obese teenagers with and without IR, the average of the biochemical variables ...

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“…2 In a recent article, Khokhar A. et al reviewed the use of metformin in paediatric and children with prediabetes condition for further development. 7 In a similar way, Hostalek UH. et al, reviewed data on the use of lower doses of metformin 250 mg qd, titrated 250 mg bid, and lifestyle intervention use in prediabetes patients of IDPP programme to prevent diabetes mellitus.…”

Section: Prediabetes Is Generally An Intermediate Condition Betweenmentioning

confidence: 91%

Prediabetes, diabetes mellitus, and anti‐diabetic treatment: Is anyone still healthy?

Jonnalagadda

Char

Samudrala

2018

Diabetes Metabolism Res

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Metformin Use in Children and Adolescents with Prediabetes

Cited by 44 publications

References 57 publications

ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 diabetes mellitus in youth

ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 diabetes mellitus in youth

Obesidad, resistencia a la insulina y diabetes mellitus tipo 2 en adolescentes

Prediabetes, diabetes mellitus, and anti‐diabetic treatment: Is anyone still healthy?

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