Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Chen, Sheng; Gan, Donghao; Lin, Sixiong; Zhong, Yiming; Chen, Mingjue; Zou, Xuenong; Shao, Zhimin; Xiao, Guozhi

doi:10.7150/thno.71360

Cited by 77 publications

(64 citation statements)

References 198 publications

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“…Positive controls were used in the study, Met and NMN. Metformin regulated the insulin and IGF-1 signaling ( 43 ), which were similar effects that SCPs exerted on C. elegans . NMN is a widespread reduction in NAD + that is connected to all of the signs and symptoms of aging.…”

Section: Discussionmentioning

confidence: 88%

Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans

Yang²,

Xu³

et al. 2022

Front. Nutr.

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The sea cucumber peptides (SCPs) from Acaudina leucoprocta were derived from the patented bio-enzyme digestion technology and the molecular weight of obtained SCPs was < 10 kDa. In this study, we investigated the possible anti-aging effects of SCPs on the model of Caenorhabditis elegans and the underlying mechanisms. SCPs extend the average lifespan of nematodes by 31.46%. SCPs enhance the anti-stress capacity of C. elegans by improving heat resistance and mobility, Also, the accumulated potential oxidative stress inducers like lipofuscin and reactive oxygen species (ROS) were reduced to 40.84 and 71.43%. In addition, SCPs can increase the antioxidant capacity in nematodes by enhancing the activity of SOD and CAT and reducing MDA accumulation in nematodes to 32.44%. Mechanistically, SCPs could mediate DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 axis to improve antioxidant capacity and extend lifespan in nematodes. Taken together, these findings provide a direction for the anti-aging effects of sea cucumber peptides and new insights into the further purifications of SCPs and future research on aging.

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Section: Discussionmentioning

confidence: 88%

Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans

Yang²,

Xu³

et al. 2022

Front. Nutr.

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“…When used in some in vivo models, metformin administration increased the lifespan of Caenorhabditis elegans [ 125 , 126 , 127 ] and mice [ 128 , 129 ]. Furthermore, metformin has been reported to benefit patients with cardiovascular diseases [ 130 ] and treat metabolic syndromes and cancer and in the prevention and treatment of aging and aging-related diseases [ 131 , 132 ].…”

Section: Dietary and Nutraceutical Strategies To Tackle Immunosenesce...mentioning

confidence: 99%

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks

et al. 2022

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Aging results from the progressive dysregulation of several molecular pathways and mTOR and AMPK signaling have been suggested to play a role in the complex changes in key biological networks involved in cellular senescence. Moreover, multiple factors, including poor nutritional balance, drive immunosenescence progression, one of the meaningful aspects of aging. Unsurprisingly, nutraceutical and pharmacological interventions could help maintain an optimal biological response by providing essential bioactive micronutrients required for the development, maintenance, and the expression of the immune response at all stages of life. In this regard, many studies have provided evidence of potential antiaging properties of resveratrol, as well as rapamycin and metformin. Indeed, in vitro and in vivo models have demonstrated for these molecules a number of positive effects associated with healthy aging. The current review focuses on the mechanisms of action of these three important compounds and their suggested use for the clinical treatment of immunosenescence and aging.

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“…Metformin was also suggested to have beneficial activity in IDD treatment. This compound was noted to stimulate autophagy, reduce local mechanical hyperalgesia, and inhibit inflammatory responses in NP and AF cells, protecting against apoptosis and senescence [ 79 , 80 ]. An in-depth study performed by Chen et al [ 81 ] concerning its mechanisms of action revealed that metformin activates autophagy in NP cells in a dose- and time-dependent manner, promotes the expression of anabolic genes, such as Col2a1 and Acan , and inhibits the expression of catabolic genes, such as MMP3 and ADAMTS5 .…”

Section: Strategies For Managing Intervertebral Disc Degenerationmentioning

confidence: 99%

Recent Advances in Managing Spinal Intervertebral Discs Degeneration

Costăchescu

Niculescu

Teleanu

et al. 2022

IJMS

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Low back pain (LBP) represents a frequent and debilitating condition affecting a large part of the global population and posing a worldwide health and economic burden. The major cause of LBP is intervertebral disc degeneration (IDD), a complex disease that can further aggravate and give rise to severe spine problems. As most of the current treatments for IDD either only alleviate the associated symptoms or expose patients to the risk of intraoperative and postoperative complications, there is a pressing need to develop better therapeutic strategies. In this respect, the present paper first describes the pathogenesis and etiology of IDD to set the framework for what has to be combated to restore the normal state of intervertebral discs (IVDs), then further elaborates on the recent advances in managing IDD. Specifically, there are reviewed bioactive compounds and growth factors that have shown promising potential against underlying factors of IDD, cell-based therapies for IVD regeneration, biomimetic artificial IVDs, and several other emerging IDD therapeutic options (e.g., exosomes, RNA approaches, and artificial intelligence).

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Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Cited by 77 publications

References 198 publications

Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans

Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks

Recent Advances in Managing Spinal Intervertebral Discs Degeneration

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