Metformin Improves Ovarian Cancer Sensitivity to Paclitaxel and Platinum-Based Drugs: A Review of In Vitro Findings

Tossetta, Giovanni

doi:10.3390/ijms232112893

Cited by 44 publications

(35 citation statements)

References 108 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The precise molecular mechanisms that support the relationship between autophagy and mitochondrial donation via TNTs and/or EVs remain to be elucidated. Data confirmed that the treatment of cancer cells with metformin can affect the formation of TNTs (Tossetta, 2022). For instance, mesothelioma and ovarian cancer cells treated with metformin exhibited the reduction of TNT formation via the inhibition of mTOR (Desir et al, 2016; Lou et al, 2012).…”

Section: Autophagy and Tntsmentioning

confidence: 55%

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle

Sadeghsoltani,

Hassanpour,

Safari

et al. 2024

Journal Cellular Physiology

View full text Add to dashboard Cite

Angiogenesis is a complex process that involves the expansion of the pre‐existing vascular plexus to enhance oxygen and nutrient delivery and is stimulated by various factors, including hypoxia. Since the process of angiogenesis requires a lot of energy, mitochondria play an important role in regulating and promoting this phenomenon. Besides their roles as an oxidative metabolism base, mitochondria are potential bioenergetics organelles to maintain cellular homeostasis via sensing alteration in oxygen levels. Under hypoxic conditions, mitochondria can regulate angiogenesis through different factors. It has been indicated that unidirectional and bidirectional exchange of mitochondria or their related byproducts between the cells is orchestrated via different intercellular mechanisms such as tunneling nanotubes, extracellular vesicles, and gap junctions to maintain the cell homeostasis. Even though, the transfer of mitochondria is one possible mechanism by which cells can promote and regulate the process of angiogenesis under reperfusion/ischemia injury. Despite the existence of a close relationship between mitochondrial donation and angiogenic response in different cell types, the precise molecular mechanisms associated with this phenomenon remain unclear. Here, we aimed to highlight the possible role of mitochondria concerning angiogenesis, especially the role of mitochondrial transport and the possible relation of this transfer with autophagy, the housekeeping phenomenon of cells, and angiogenesis.

show abstract

Section: Autophagy and Tntsmentioning

confidence: 55%

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle

Sadeghsoltani,

Hassanpour,

Safari

et al. 2024

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Presently, synthetic chemotherapeutics are widely involved in solid tumor therapy together with radiotherapy and surgical operations. For instance, platinum-based antitumor drugs (such as cisplatin, carboplatin, oxaliplatin, satraplatin, and nedaplatin) [ 1 , 2 , 3 , 4 , 5 , 6 ], lonidamine, doxorubicin, and methotrexate [ 7 ] are commonly used chemotherapeutics in treating solid tumors. Despite their therapeutic anticancer effects, clinicians and patients still suffer from treatment failure of chemotherapeutic agents (even the latest generations) due to their systemic toxicity and cancer cells’ resistance [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

Youness¹,

Al-mahallawi

Mahmoud³

et al. 2023

Polymers

View full text Add to dashboard Cite

This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. In this regard, uncoated bilosomes loaded with Ps (Ps/BLs) were nanoformulated using the thin-film hydration technique using different molar ratios of phosphatidylcholine (PC), cholesterol (Ch), Span 60 (S60), and sodium deoxycholate (SDC) (1:0.4:0.2:0.125, 1:0.4:0.2:0.25, and 1:0.4:0.2:0.5, respectively). The best-optimized formulation with respect to size, PDI, zeta potential, and EE% was selected and then coated with chitosan at two different concentrations (0.125 and 0.25 w/v%), forming Ps-CS/BLs. The optimized Ps/BLs and Ps-CS/BLs showed a spherical shape and relatively homogenous size with negligible apparent agglomerations. Additionally, it was demonstrated that coating Ps/BLs with chitosan has significantly increased the particle size from 123.16 ± 6.90 in the case of Ps/BLs to 183.90 ± 15.93 nm in the case of Ps-CS/BLs. In addition, Ps-CS/BLs exhibited higher zeta potential (+30.78 ± 1.44 mV) as compared to Ps/BLs (−18.59 ± 2.13 mV). Furthermore, Ps-CS/BL showed enhanced entrapment efficiency (EE%) of 92.15 ± 7.20% as compared to Ps/BLs (68.90 ± 5.95%). Moreover, Ps-CS/BLs exhibited a more sustained release behavior of Ps compared to Ps/BLs over 48 h, and both formulations were best obeying the Higuchi diffusion model. More importantly, Ps-CS/BLs displayed the highest mucoadhesive efficiency% (74.89 ± 3.5%) as compared to Ps/BLs (26.78 ± 2.9%), indicating the ability of the designed nanoformulation to improve oral bioavailability and extend the residence time inside the gastrointestinal tract upon oral administration. Moreover, upon evaluating the apoptotic and necrotic effects of free Ps and Ps-CS/BLs on human breast cancer cell lines (MCF-7) and human lung adenocarcinoma cell lines (A549), there was a dramatic increase in the percentages of the apoptotic and necrotic cell compared to the control and free Ps. Our findings suggest the possible oral use of Ps-CS/BLs in hampering breast and lung cancers.

show abstract

“…Because this disease is usually asymptomatic or has nonspecific symptoms, more than 75% of patients are diagnosed at an advanced stage [ 2 ]. Moreover, the occurrence of chemoresistance also weakens the therapeutic effects of chemotherapeutic treatments [ 3 ]. Thus, the 5-year survival rate of OC is below 45% [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study

Gong

Wei

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown. Methods: A total of 703 newly diagnosed patients with OC aged 18–79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants’ dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized. Results: During the median follow-up of 31 months (interquartile: 20–47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19–0.80; p trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29–0.94, p trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (p non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (p < 0.05), respectively. Conclusion: A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.

show abstract

Metformin Improves Ovarian Cancer Sensitivity to Paclitaxel and Platinum-Based Drugs: A Review of In Vitro Findings

Cited by 44 publications

References 108 publications

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study

Contact Info

Product

Resources

About