Metformin delivery via iontophoresis based on κ-carrageenan cryogels

Saramas, Tidayu; Sakunpongpitiporn, Phimchanok; Rotjanasuworapong, Kornkanok; Morarad, Rawita; Niamlang, Sumonman; Sirivat, Anuvat

doi:10.1016/j.ijbiomac.2022.11.098

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…The total amount of medication released decreased with increasing gelatin concentration and dosage. An in vitro and in vivo toxicity research study of pectin-acrylamide-fabricated hydrogels was used to assess the generated hydrogel by Saramas et al, 55 which was done using cross-linked N , N -methylene bisacrylamide. The proportions of drug release, permeation, and diffusion coefficients were increased with shorter times in comparison to no electrical potential for the drug release permeation of the C 0.8% v/v cryogel via the pig skin.…”

Section: Oscillatory Frequency Sweep Measurementsmentioning

confidence: 99%

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Mir,

Fletcher,

Taylor

et al. 2024

ACS Omega

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The present work highlights the synthesis and characterization of conducting polymer (CP)-based composite hydrogels with gelatin (GL-B) for their application as drug delivery vehicles. The spectral, morphological, and rheological properties of the synthesized hydrogels were explored, and morphological studies confirmed formation of an intense interpenetrating network. Rheological measurements showed variation in the flow behavior with the type of conducting polymer. The hydrogels showed a slow drug release rate of about 10 h due to the presence of the conducting polymer. The release kinetics were fitted in various mathematical models and were best fit in first order for PNA-, POPD-, and PANI-based GL-B hydrogels, and the PVDF/GL-B hydrogel was best fit in the zero-order models. The drug release was found to follow the order: POPD/GL-B > PANI/GL-B > PVDF/GL-B.

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Section: Oscillatory Frequency Sweep Measurementsmentioning

confidence: 99%

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Mir,

Fletcher,

Taylor

et al. 2024

ACS Omega

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“…With increasing pore size, the diffusion coefficient for Metformin slightly increased and the application of a positive electrical potential shorted the time of equilibrium of the drug, enhancing the release rate from the matrix. By combining κ -CRG’s properties and electrical potential, it was then possible to increase and control the transdermal release of Metformin [ 59 ].…”

Section: Natural Hydrogelsmentioning

confidence: 99%

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Dattilo

Patitucci

Prete

et al. 2023

JFB

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Hydrogels are three-dimensional crosslinked structures with physicochemical properties similar to the extracellular matrix (ECM). By changing the hydrogel’s material type, crosslinking, molecular weight, chemical surface, and functionalization, it is possible to mimic the mechanical properties of native tissues. Hydrogels are currently used in the biomedical and pharmaceutical fields for drug delivery systems, wound dressings, tissue engineering, and contact lenses. Lately, research has been focused on hydrogels from natural sources. Polysaccharides have drawn attention in recent years as a promising material for biological applications, due to their biocompatibility, biodegradability, non-toxicity, and excellent mechanical properties. Polysaccharide-based hydrogels can be used as drug delivery systems for the efficient release of various types of cancer therapeutics, enhancing the therapeutic efficacy and minimizing potential side effects. This review summarizes hydrogels’ classification, properties, and synthesis methods. Furthermore, it also covers several important natural polysaccharides (chitosan, alginate, hyaluronic acid, cellulose, and carrageenan) widely used as hydrogels for drug delivery and, in particular, their application in cancer treatment.

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“…The amounts of metformin release at 0, 3, and 6 V were 92.97%, 95.47%, and 96.72%, whereas the times to equilibrium were 7, 4.5, and 2 h, respectively. 32 Mongkolkitikul et al studied the ibuprofen release where pectin and poly(3-methoxydiphenylamine) (P3DPA) were used as the hydrogel matrix and the conductive polymer, respectively. 33 Paradee et al studied the diclofenac release where dextran and poly(2-ethylaniline) (PEAn) were used as the matrix hydrogel and the conductive polymer, respectively.…”

Section: Introductionmentioning

confidence: 99%

Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as an insulin carrier in silk fibroin hydrogels for transdermal delivery via iontophoresis

Sakunpongpitiporn,

Morarad,

Naeowong

et al. 2024

RSC Adv.

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Metformin delivery via iontophoresis based on κ-carrageenan cryogels

Cited by 9 publications

References 37 publications

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as an insulin carrier in silk fibroin hydrogels for transdermal delivery via iontophoresis

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