Metformin and sleep disorders

Wiwanitkit, Somsri; Wiwanitkit, Viroj

doi:10.4103/2230-8210.94262

Cited by 9 publications

(13 citation statements)

References 10 publications

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“…It was observed that insomnia symptom scales did not show a statistically significant difference between the metformin group and the control group. This result is against the Wiwanitkit et al (2012), which showed that metformin, the insulin sensitizer, can lead to sleep disturbance, which may affect patterns of normal dreams 88 .…”

Section: Discussionmentioning

confidence: 80%

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial

Barakat

Hussein

Elberry

et al. 2022

Sci Rep

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Recently, several clinical trials have attempted to find evidence that supports the anticancer use of metformin in breast cancer (BC) patients. The current study evaluates the anticancer activity of metformin in addition to neoadjuvant chemotherapy (NACT) in locally advanced BC patients. Additionally, we assess the safety and tolerability of this combination and its effect on the quality of life (QoL) of BC patients. Eighty non-diabetic female patients with proven locally advanced BC were randomized into two arms. The first arm received anthracycline/taxane-based NACT plus metformin. The second arm received anthracycline/taxane-based NACT only. Overall response rate (ORR), clinical complete response (cCr), pathological complete response (pCR), and breast conservative rate (BCR) were evaluated between both groups, and correlated with serum metformin concentration. ORR, cCr, pCR, and BCR increased non-significantly in the metformin group compared to the control group; 80.6% vs 68.4%, 27.8% vs 10.5%, 22.2% vs 10.5%, and 19.4% vs 13.2%, respectively. A trend towards cCR and pCR was associated with higher serum metformin concentrations. Metformin decreased the incidence of peripheral neuropathy, bone pain, and arthralgia, although worsened the gastrointestinal adverse events. Metformin combination with NACT has no effect on the QoL of BC patients. Metformin combination with NACT is safe, tolerable, and improves non-significantly the clinical and pathological tumor response of BC patients.

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Section: Discussionmentioning

confidence: 80%

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial

Barakat

Hussein

Elberry

et al. 2022

Sci Rep

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“…The cause is still uncertain but the changes in blood glucose levels that may occur after starting therapy with metformin might be a possible mechanism. 40 …”

Section: Discussionmentioning

confidence: 97%

Effect of Metformin on Sleep Disorders in Adolescent Girls with Polycystic Ovarian Syndrome

El-Sharkawy¹,

Abdelmotaleb²,

Aly³

et al. 2014

Journal of Pediatric and Adolescent Gynecology

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“…While there were many numerous reviews and meta-analyses of metformin adverse effects, only a brief review and a case report mentioned the possible causality of metformin-induced nightmare and abnormal dreams [13, 14]. Nonformal accounts of these occurrence were reported from eHealthMe.com, a website which is used as patient self-reporting adverse drug effects and primarily connects with the data from US Food and Drug Administration (FDA), with possible overall prevalence of 0.17% and 0.23% over 200,000 people who routinely took metformin [15, 16].…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral blood glucose levels during the night seems to play a key role in explaining the occurrence of nightmare and abnormal dreams in this case [13]. Nocturnal hypoglycemia is often clinically asymptomatic, but it could cause problems related to abnormal dreams and poor sleep quality in some individuals [17].…”

Section: Discussionmentioning

confidence: 99%

Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?

Yanto

Huang

Kosasih

et al. 2018

Case Reports in Endocrinology

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Background Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after consumption of 750 mg extended release metformin. He reported his dream as an unpleasant experience which awakened him at night with negative feelings. The nightmare only lasted for a night, but his dreams every night thereafter seemed abnormal. The dreams were vivid and indescribable. The disappearance and occurrence of abnormal dreams ensued soon after the drug was discontinued and rechallenged. The case was assessed using Naranjo Adverse Drug Reaction (ADR) probability scale and resulted as probable causality. Conclusion Metformin might be the underlying cause of nightmare and abnormal dreams in this patient. More studies are needed to confirm the association and causality of this findings.

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Metformin and sleep disorders

Abstract: Metformin is a widely used anti-diabetic drug. Deterioration of sleep is an important unwanted side effect of metformin. Here, the authors review and present the details on metformin and sleep problem.

Cited by 9 publications

References 10 publications

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial

Effect of Metformin on Sleep Disorders in Adolescent Girls with Polycystic Ovarian Syndrome

Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?

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