Effect of Metformin on Sleep Disorders in Adolescent Girls with Polycystic Ovarian Syndrome

El-Sharkawy, Ahmed A.; Abdelmotaleb, Ghada S.; Aly, Mohammed K.; Kabel, Ahmed M.

doi:10.1016/j.jpag.2014.01.004

Cited by 38 publications

(30 citation statements)

References 35 publications

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“…Besides standard methods of sleep disorders treatment there are some new approaches to PCOS therapy. There are some available reports, that metformin therapy reduces the intensity of sleep disturbances and daytime sleepiness in adolescent girls with PCOS [26]. An effective treatment for OSA causing sleep disorders in PCOS patients is using continuous positive airway pressure (CPAP), which leads to improving insulin sensitivity and decreasing diastolic blood pressure [27].…”

Section: Discussionmentioning

confidence: 99%

Sleep disturbances in women with polycystic ovary syndrome

Franik

Krysta

Madej

et al. 2016

Gynecological Endocrinology

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Sleep disturbances in women with Polycystic Ovary Syndrome (PCOS) have been reported in recent years. The majority of published studies are related to Obstructive Sleep Apnea (OSA) while not many researches have analyzed any other causes of sleep disturbances. A group of ninety five women with Polycystic Ovary Syndrome were enrolled into the study. Sleep disturbances were assessed using validated questionnaires. On the grounds of Athens Insomnia Scale (AIS) evaluation a clinically significant insomnia was ascertained in 12.6% of women with PCOS, while according to Insomnia Severity Index (ISI) in 10.5%. Clinically significant insomnia according to both AIS and ISI, occurred significantly more often in women with PCOS than in women without PCOS based on the chi-square test. The Mann-Whitney U test revealed statistically significant difference between women with and without PCOS based on total values of ISI. An excessive daytime sleepiness occurred at 7.4% of women with PCOS. Statistically significant dependance between: clinically significant insomnia in both AIS and ISI and excessive daytime sleepiness indicated by Epworth Sleepiness Scale (ESS) was observed. Sleep disorders are common in women with PCOS. Screening assessment of sleep disturbances should be a part of medical diagnostics in women with PCOS.

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Section: Discussionmentioning

confidence: 99%

Sleep disturbances in women with polycystic ovary syndrome

Franik

Krysta

Madej

et al. 2016

Gynecological Endocrinology

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“…These trials have also shown improvements related to hirsutism, ovulation, quality of life, sleep, lipid profile, adipocytokine levels, and insulin resistance [148][149][150][151][152][153][154][155][156][157][158][159][160] . However, most trials have been limited by their short Witchel et [133,135,[161][162][163] .…”

Section: Recommendationsmentioning

confidence: 99%

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

et al. 2015

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dress a series of questions regarding the diagnosis of PCOS during adolescence including the following: clinical and biochemical evidence of hyperandrogenism, criteria for oligoanovulation and polycystic ovary morphology, diagnostic criteria to exclude other causes of hyperandrogenism and amenorrhea, role of insulin resistance, and intervention. Results and Conclusion: Features of PCOS overlap normal pubertal development. Hence, caution should be taken before diagnosing PCOS without longitudinal evaluation. However, treatment may be indicated even in the absence of a definitive diagnosis. While obesity, insulin resistance, and hyperinsulinemia are common findings in adolescents with hyperandrogenism, these features should not be used to diagnose PCOS among adolescent girls. © 2015 S. Karger AG, Basel Key WordsHyperandrogenism · Ovarian hyperandrogenism · Ovary · Polycystic ovary syndrome · Puberty Abstract Background/Aims: The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological events. Hence, international pediatric and adolescent specialty societies have defined criteria that have sufficient evidence to be used for the diagnosis of PCOS in adolescents. Methods: The literature has been reviewed and evidence graded to ad-

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“…In a study, metformin supplementation to individuals diagnosed with PCOS decreased ESS compared to untreated group, although continued to be in the abnormal range, suggesting insulin resistance as a contributing factor for EDS [12]. Visceral fat and cytokines (interleukin-6 and tumor necrosis factor α) has been attributed to EDS as well.…”

Section: Discussionmentioning

confidence: 99%

Polycystic Ovarian Syndrome and Narcolepsy: A Coincidental Relationship?

Lee¹

2017

J Sleep Disord Manag

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A relationship between Polycystic Ovarian Syndrome (PCOS) and narcolepsy has not been well examined. Both disorders share common comorbidities including obesity, Obstructive Sleep Apnea (OSA), and excessive daytime sleepiness (EDS). However, it is not clear if these two disorders sporadically coexist or are commonly occurring and missed. Low or deficient hypocretin level as well as other hormonal abnormalities might explain this association. Authors present one case presentation supported by three other published cases and literature review about this comorbidity.

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Effect of Metformin on Sleep Disorders in Adolescent Girls with Polycystic Ovarian Syndrome

Cited by 38 publications

References 35 publications

Sleep disturbances in women with polycystic ovary syndrome

Sleep disturbances in women with polycystic ovary syndrome

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

Polycystic Ovarian Syndrome and Narcolepsy: A Coincidental Relationship?

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