Metatranscriptome deciphers the effects of non-antibiotic antimicrobial agents on antibiotic resistance and virulence factors in freshwater microcosms

Wang, Yan; Ni, Kepin; Zhang, Zhenyan; Xu, Nuohan; Lei, Chaotang; Chen, Bingfeng; Zhang, Qi; Sun, Liwei; Lu, Tao; Qian, Haifeng

doi:10.1016/j.aquatox.2023.106513

Cited by 4 publications

(1 citation statement)

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“… 40 Additionally, it is essential to profile transcriptomics, metatranscriptomics and biological processes through functional enrichment methods. 41 Metatranscriptomics provides valuable insights into the active micro-organisms present in a specific environment and their ability to encode specific gene products. Since gene expression plays a significant role in phenotypic expression, investigating differences in gene expression between various conditions, including the presence and absence of a disease, can aid in comprehending the molecular mechanisms responsible for human disorders.…”

Section: Introductionmentioning

confidence: 99%

Gut virome in inflammatory bowel disease and beyond

Tun,

Peng,

Massimino

et al. 2023

Gut

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ObjectiveThe gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibrium, serving as a key contributor to the maintenance of intestinal homeostasis and functions. However, this equilibrium can be interrupted in certain pathological states, including inflammatory bowel disease, causing dysbiosis that may participate in disease pathogenesis. Nevertheless, whether virome dysbiosis is a causal or bystander event requires further clarification.DesignThis review seeks to summarise the latest advancements in the study of the gut virome, highlighting its cross-talk with the mucosal microenvironment. It explores how cutting-edge technologies may build upon current knowledge to advance research in this field. An overview of virome transplantation in diseased gastrointestinal tracts is provided along with insights into the development of innovative virome-based therapeutics to improve clinical management.ResultsGut virome dysbiosis, primarily driven by the expansion ofCaudovirales, has been shown to impact intestinal immunity and barrier functions, influencing overall intestinal homeostasis. Although emerging innovative technologies still need further implementation, they display the unprecedented potential to better characterise virome composition and delineate its role in intestinal diseases.ConclusionsThe field of gut virome is progressively expanding, thanks to the advancements of sequencing technologies and bioinformatic pipelines. These have contributed to a better understanding of how virome dysbiosis is linked to intestinal disease pathogenesis and how the modulation of virome composition may help the clinical intervention to ameliorate gut disease management.

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Section: Introductionmentioning

confidence: 99%